Reactome | AKR1C1 hydrogenates PREDN,PREDL

AKR1C1 hydrogenates PREDN,PREDL

Stable Identifier

R-HSA-9758682

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phase I metabolic reactions of prednisone (PREDN) and prednisolone (PREDL) include oxidation of the hydroxyl group in C11, reduction of ketone in C20, hydroxylation in C6, or a combination of some of them. Probably one or more of the AKR1C family enzymes reduce PREDN, PREDL to their 20alpha- and beta forms which are detected in urine. The enzymatic mechanism has not been exhaustively explored (Mazzarino et al, 2019; Penning et al, 2019).

Literature References

PubMed ID	Title	Journal	Year
31701669	Urinary excretion profile of prednisone and prednisolone after different administration routes Piantadosi, C, Comunità, F, Mazzarino, M, de la Torre, X, Botrè, F	Drug Test Anal	2019
30137266	Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes Penning, TM, Wangtrakuldee, P, Auchus, RJ	Endocr Rev	2019