Reactome | UGT2B7,2B17,1A3 glucuronidates PRED metabolites

UGT2B7,2B17,1A3 glucuronidates PRED metabolites

Stable Identifier

R-HSA-9758661

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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UGT2B7,2B17,1A3 glucuronidates PRED metabolites

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UDP-glucuronosyltransferase 2B7 (UGT2B7) was found in vitro to be the main enzyme glucuronidating prednisone (PREDN) with UGT2B17 and UGT1A3 having weak activity (Innocenti et al, 2005). It is probable that these glucuronosyltransferases are responsible for glucuronidation of other PREDN metabolites that show up in urinary output (Matabosch et al, 2015; Mazzarino et al, 2019).

Literature References

PubMed ID	Title	Journal	Year
	In vitro Glucuronidation of Prednisone Innocenti, F, Yoder Graber, A, Ramirez, J, Ratain, MJ
25800201	Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS Matabosch, X, Pozo, OJ, Pérez-Mañá, C, Papaseit, E, Segura, J, Ventura, R	J Mass Spectrom	2015
31701669	Urinary excretion profile of prednisone and prednisolone after different administration routes Mazzarino, M, Piantadosi, C, Comunità, F, de la Torre, X, Botrè, F	Drug Test Anal	2019