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MIXL1 [nucleoplasm]
Stable Identifier
R-HSA-9758510
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Homeobox protein MIXL1, MIXL1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of definitive endoderm (Homo sapiens)
EOMES, SMAD2,3, MIXL1 bind the GSC gene (Homo sapiens)
EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
Expression of GSC in definitive endoderm (Homo sapiens)
EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
Expression of SOX17 in definitive endoderm (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
Germ layer formation at gastrulation (Homo sapiens)
Expression of MIXL1 in the primitive streak (Homo sapiens)
MIXL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H2W2 MIXL1
Gene Names
MIXL1, MIXL
Chain
chain:1-232
Reference Genes
BioGPS Gene:83881 MIXL1
COSMIC (genes):MIXL1 MIXL1
CTD Gene:83881 MIXL1
dbSNP Gene:83881 MIXL1
ENSEMBL:ENSG00000185155 MIXL1
HGNC:13363 MIXL1
KEGG:hsa:83881 MIXL1
Monarch:83881 MIXL1
NCBI Gene:83881 MIXL1
OMIM:609852 MIXL1
UCSC:Q9H2W2 MIXL1
Reference Transcript
RefSeq:NM_031944.2 MIXL1
RefSeq:NM_001282402.1 MIXL1
Other Identifiers
11735375_at
16678149
231746_PM_at
231746_at
2383119
2383120
2383121
2383122
2383123
2383124
2383125
2383126
2383127
2383129
3203077
7910134
83881
A_23_P11739
A_33_P3279550
GE83283
GO:0000785
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001706
GO:0002244
GO:0003677
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0007369
GO:0007492
GO:0007507
GO:0030097
GO:0030154
GO:0035987
GO:0042074
GO:0042802
GO:0042803
GO:0043226
GO:0045944
GO:0048565
GO:0048856
GO:0048870
GO:0061629
GO:0140110
GO:1901533
GO:1990837
GO:2000382
HMNXSV003019755
Hs.282079.0.S1_3p_at
ILMN_1668969
PH_hs_0014491
PH_hs_0036367
TC01001860.hg
Participates
as a component of
EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
as an input of
EOMES, SMAD2,3, MIXL1 bind the GSC gene (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
as an output of
Expression of MIXL1 in the primitive streak (Homo sapiens)
This entity regulates
Positively
Expression of E-cadherin (CDH1) in definitive endoderm
(Homo sapiens)
Expression of SOX17 in definitive endoderm
(Homo sapiens)
Cross References
ENSEMBL
ENST00000542034
,
ENSP00000442439
,
ENST00000366810
,
ENSG00000185155
,
ENSP00000355775
OpenTargets
ENSG00000185155
GeneCards
MIXL1
HPA
ENSG00000185155-MIXL1
PRO
Q9H2W2
Pharos - Targets
Q9H2W2
GlyGen
Q9H2W2
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