Reactome | Expression of MIXL1 in the primitive streak

Expression of MIXL1 in the primitive streak

Stable Identifier

R-HSA-9758501

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Expression of MIXL1 in the primitive streak

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During gastrulation, MIXL1 is expressed throughout the primitive streak and the nascent mesoderm, but then becomes localized to the anterior and posterior ends of the streak (inferred from the mouse homolog in mouse embryos, inferred from the non-human primate Macaca fascicularis in Nakamura et al. 2016, Sasaki et al. 2016). Transcription of MIXL1 is activated by NODAL via SMAD2,3, EOMES, and by WNT via beta-catenin (CTNNB1) (Teo et al. 2011, Funa et al. 2015, and inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
21245162	Pluripotency factors regulate definitive endoderm specification through eomesodermin Dunn, NR, Chng, Z, Trotter, MW, Vallier, L, Teo, AK, Ang, LT, Brown, S, Arnold, SJ, Robertson, EJ	Genes Dev.	2011
25921273	β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4 Hess, K, Semb, H, Dietrich, N, Lerdrup, M, Funa, NS, Schachter, KA, Honoré, C, Ekberg, J, Hansen, K	Cell Stem Cell	2015