Trimming of mannoses on the alpha1,6 arm by MAN2A1

Stable Identifier
R-HSA-975814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The removal of mannoses on the alpha,1,6 arm by MAN2A1 or MAN2A2 is required for efficient formation of complex-type N-glycans (Misago M et al, 1995; Crispin M et al, 2007). These two enzymes carry out the same function and the disruption of both inhibits the formation of complex N-glycans in vivo (Akama TO et al, 2006).
Literature References
PubMed ID Title Journal Year
16754854 Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice

Nakagawa, H, Marth, JD, Pai, A, Dell, A, Nakayama, J, Morris, HR, Akama, TO, Moremen, KW, Nishimura, S, Fukuda, MN, Sutton-Smith, M, Wong, NK

Proc Natl Acad Sci U S A 2006
8524845 Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme

Misago, M, Eto, S, Kudo, S, Moremen, KW, Mattéi, MG, Fukuda, MN, Liao, YF

Proc Natl Acad Sci U S A 1995
17466984 Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation

Davis, SJ, Jones, EY, Crispin, M, Aricescu, AR, Harvey, DJ, Stuart, DI, Chang, VT, Dwek, RA

FEBS Lett 2007
Participants
Participates
Catalyst Activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity of MAN2:Zn2+ [Golgi membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!