The removal of mannoses on the alpha,1,6 arm by MAN2A1 or MAN2A2 is required for efficient formation of complex-type N-glycans (Misago M et al, 1995; Crispin M et al, 2007). These two enzymes carry out the same function and the disruption of both inhibits the formation of complex N-glycans in vivo (Akama TO et al, 2006).
Misago, M, Liao, YF, Kudo, S, Eto, S, Mattéi, MG, Moremen, KW, Fukuda, MN
Akama, TO, Nakagawa, H, Wong, NK, Sutton-Smith, M, Dell, A, Morris, HR, Nakayama, J, Nishimura, S, Pai, A, Moremen, KW, Marth, JD, Fukuda, MN
Crispin, M, Aricescu, AR, Chang, VT, Jones, EY, Stuart, DI, Dwek, RA, Davis, SJ, Harvey, DJ
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