Reactome | Trimming of mannoses on the alpha1,6 arm by MAN2A1

Trimming of mannoses on the alpha1,6 arm by MAN2A1

Stable Identifier

R-HSA-975814

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Homo sapiens)

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Trimming of mannoses on the alpha1,6 arm by MAN2A1

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The removal of mannoses on the alpha,1,6 arm by MAN2A1 or MAN2A2 is required for efficient formation of complex-type N-glycans (Misago M et al, 1995; Crispin M et al, 2007). These two enzymes carry out the same function and the disruption of both inhibits the formation of complex N-glycans in vivo (Akama TO et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16754854	Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice Akama, TO, Nakagawa, H, Wong, NK, Sutton-Smith, M, Dell, A, Morris, HR, Nakayama, J, Nishimura, S, Pai, A, Moremen, KW, Marth, JD, Fukuda, MN	Proc Natl Acad Sci U S A	2006
8524845	Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme Misago, M, Liao, YF, Kudo, S, Eto, S, Mattéi, MG, Moremen, KW, Fukuda, MN	Proc Natl Acad Sci U S A	1995
17466984	Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation Crispin, M, Aricescu, AR, Chang, VT, Jones, EY, Stuart, DI, Dwek, RA, Davis, SJ, Harvey, DJ	FEBS Lett	2007