Trimming of mannoses on the alpha1,6 arm by MAN2A1

Stable Identifier
Reaction [transition]
Homo sapiens
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The removal of mannoses on the alpha,1,6 arm by MAN2A1 or MAN2A2 is required for efficient formation of complex-type N-glycans (Misago M et al, 1995; Crispin M et al, 2007). These two enzymes carry out the same function and the disruption of both inhibits the formation of complex N-glycans in vivo (Akama TO et al, 2006).

Literature References
PubMed ID Title Journal Year
16754854 Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice

Nakagawa, H, Marth, JD, Pai, A, Dell, A, Nakayama, J, Morris, HR, Akama, TO, Moremen, KW, Nishimura, S, Fukuda, MN, Sutton-Smith, M, Wong, NK

Proc Natl Acad Sci U S A 2006
8524845 Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme

Misago, M, Eto, S, Kudo, S, Moremen, KW, Mattéi, MG, Fukuda, MN, Liao, YF

Proc Natl Acad Sci U S A 1995
17466984 Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation

Davis, SJ, Jones, EY, Crispin, M, Aricescu, AR, Harvey, DJ, Stuart, DI, Chang, VT, Dwek, RA

FEBS Lett 2007
Catalyst Activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity of MAN2:Zn2+ [Golgi membrane]

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