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p-S139-H2AFX-Nucleosome
Stable Identifier
R-HSA-975776
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleosome with Histone gamma-H2A.x
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic heteroduplex (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Meiotic synapsis (Homo sapiens)
ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
ATM phosphorylates MDC1 (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
ATM phosphorylates WHSC1 (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
MDC1 associates with gamma-H2AFX at nuclear foci (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
WHSC1 binds DNA DSBs (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Homo sapiens)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic heteroduplex (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Meiotic synapsis (Homo sapiens)
ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] (Homo sapiens)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Participants
components
2 x
HIST1H4 [nucleoplasm] (Homo sapiens)
2 x
HIST3H3 [nucleoplasm] (Homo sapiens)
2 x
Histone H2B [nucleoplasm] (Homo sapiens)
2 x
p-S140-H2AFX [nucleoplasm] (Homo sapiens)
Participant Of
hasComponent
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm]
Meiotic D-loop complex [nucleoplasm]
Meiotic single-stranded DNA complex [nucleoplasm]
Unsynapsed chromatin with gamma-H2A.x [nucleoplasm]
Inferred To
p-S139-H2AFX-Nucleosome [nucleoplasm] (Arabidopsis thaliana)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Bos taurus)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Danio rerio)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Drosophila melanogaster)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Gallus gallus)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Oryza sativa)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Rattus norvegicus)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Sus scrofa)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Taeniopygia guttata)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
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