Reactome | HSD11B1 hydrogenates PREDN to PREDL in hepatic cell

HSD11B1 hydrogenates PREDN to PREDL in hepatic cell

Stable Identifier

R-HSA-9757706

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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HSD11B1 hydrogenates PREDN to PREDL in hepatic cell

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Prednisone (PREDN) is hydrogenated to prednisolone (PREDL) by HSD11B1. The conversion of 11β-hydroxysteroids to 11-oxosteroids and vice versa is catalyzed by the enzymes 11β-hydroxysteroid dehydrogenase 1 and 2 (HSD11B1, HSD11B2). Although the activity of both enzymes is bidirectional in vitro, in vivo HSD11B1 acts as 11-oxosteroid reductase and HSD11B2 acts as 11β-hydroxysteroid dehydrogenase (Jamieson et al, 1995). HSD11B1 is ubiquitously expressed, with maximum activity in the liver, while HSD11B2 is mainly active in placenta, colon, and kidney cells (Ricketts et al, 1998).

Literature References

PubMed ID	Title	Journal	Year
17200165	Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis Tomlinson, JW, Sherlock, M, Hughes, B, Hughes, SV, Kilvington, F, Bartlett, W, Courtney, R, Rejto, P, Carley, W, Stewart, PM	J Clin Endocrinol Metab	2007
12466373	11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids Diederich, S, Eigendorff, E, Burkhardt, P, Quinkler, M, Bumke-Vogt, C, Rochel, M, Seidelmann, D, Esperling, P, Oelkers, W, Bähr, V	J Clin Endocrinol Metab	2002
9543163	Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues Ricketts, ML, Verhaeg, JM, Bujalska, I, Howie, AJ, Rainey, WE, Stewart, PM	J Clin Endocrinol Metab	1998
7588203	11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations Jamieson, PM, Chapman, KE, Edwards, CR, Seckl, JR	Endocrinology	1995