Reactome | ALB binds PREDN

ALB binds PREDN

Stable Identifier

R-HSA-9757578

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Distribution and free concentration of various drugs can be significantly altered as a result of their binding to serum albumin (ALB). ALB binds prednisone (PREDN) in a linear fashion. The binding is weak but, due to albumin availability, ALB bound PREDN represents a significant part of plasma protein bound PREDN at any point in time. Around 5% of total cortisol is known to be present in unbound form in plasma, and it is likely the number for PREDN is similar (Lewis et al, 2005). Prednisone and prednisolone do not displace each other at the albumin binding site (Boudinot and Jusko, 1984; Ferry and Wagner, 1987).

Literature References

PubMed ID	Title	Journal	Year
6492791	Plasma protein binding interaction of prednisone and prednisolone Boudinot, FD, Jusko, WJ	J Steroid Biochem	1984
15904907	Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin Lewis, JG, Bagley, CJ, Torpy, DJ, Elder, PA, Bachmann, AW	Clin Chim Acta	2005
3593903	The nonlinear pharmacokinetics of prednisone and prednisolone. II. Plasma protein binding of prednisone and prednisolone in rabbit and human plasma Ferry, JJ, Wagner, JG	Biopharm Drug Dispos	1987