ALB binds PREDL

Stable Identifier
R-HSA-9757574
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Distribution and free concentration of various drugs can be significantly altered as a result of their binding to serum albumin (ALB). ALB binds prednisolone (PREDL) weakly, but with an affinity 300 times greater than that of cortisol (Rocci et al, 1982). Due to ALB availability, ALB bound PREDL represents a significant part of plasma protein bound PREDL at any point in time. Prednisone (PREDN) and PREDL do not displace each other at the albumin binding site (Boudinot and Jusko, 1984; Ferry and Wagner, 1987).
Literature References
PubMed ID Title Journal Year
6492791 Plasma protein binding interaction of prednisone and prednisolone

Boudinot, FD, Jusko, WJ

J Steroid Biochem 1984
7073761 Prednisolone binding to albumin and transcortin in the presence of cortisol

D'Ambrosio, R, Rocci, ML, Johnson, NF, Jusko, WJ

Biochem Pharmacol 1982
7400951 Serum protein binding of prednisolone in four species

Rocci, ML, Johnson, NF, Jusko, WJ

J Pharm Sci 1980
3593903 The nonlinear pharmacokinetics of prednisone and prednisolone. II. Plasma protein binding of prednisone and prednisolone in rabbit and human plasma

Ferry, JJ, Wagner, JG

Biopharm Drug Dispos 1987
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