ABCB1,ABCC2 transport ATVs from cytosol to extracellular region

Stable Identifier
R-HSA-9757139
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
MRPs transport ATV and its metabolites into bile
ReviewStatus
5/5
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ABCB1,ABCC2 transport ATVs from cytosol to extracellular region
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ATP-binding cassette sub-family C member 2 (ABCC2, aka MRP2) (Ellis et al. 2013) and ATP-dependent translocase ABCB1 (ABCB1, aka P-glycoprotein 1) (Hochman et al. 2004) mediate the efflux of atorvastatin (ATV) and its lactone intermediates into bile.
Literature References
PubMed ID Title Journal Year
15497697 Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin

Hochman, JH, Pudvah, N, Qiu, J, Yamazaki, M, Tang, C, Lin, JH, Prueksaritanont, T

Pharm Res 2004
23562342 ATP-dependent transport of statins by human and rat MRP2/Mrp2

Ellis, LC, Hawksworth, GM, Weaver, RJ

Toxicol Appl Pharmacol 2013
Participants
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Output
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as an event of
Catalyst Activity

ABC-type xenobiotic transporter activity of ABCB1,ABCC2 [plasma membrane]

Physical Entity
ABCB1,ABCC2 [plasma membrane] (Homo sapiens)
Activity
ABC-type xenobiotic transporter activity (GO:0008559)
Orthologous Events
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Bos taurus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Caenorhabditis elegans)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Canis familiaris)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Danio rerio)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Dictyostelium discoideum)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Drosophila melanogaster)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Gallus gallus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Mus musculus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Plasmodium falciparum)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Rattus norvegicus)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Schizosaccharomyces pombe)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Sus scrofa)
ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Xenopus tropicalis)
Authored
Jassal, B  (2021-10-27)
Reviewed
Huddart, R  (2022-03-01)
Created
Jassal, B  (2021-10-27)
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