Reactome | SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol

SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol

Stable Identifier

R-HSA-9757010

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

Synonyms

Organic anion transporters transport ATV from blood into hepatocytes

ReviewStatus

5/5

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SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol

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Solute carrier organic anion transporter family members OATP1B1, OATP1B3 and OATP2B1, encoded by the SLCO1B1 (Hsiang et al. 1999), SLCO1B3 (Schwarz et al. 2011) and SLCO2B1‑3 (Knauer et al. 2013) genes, respectively, are expressed on the sinusoidal membrane of hepatocytes and can facilitate the liver uptake of atorvastatin (ATV) (review Kalliokoski & Niemi 2009). SLCO1B1 was shown to have the highest ATV uptake activity of the SLCO transporters (Vildhede et al. 2014). In a candidate-gene pharmacogenetic study, results suggested that SLCO1B1 was the best predictor for ATV pharmacokinetic variability and therefore ATV should be prescribed accordingly (Zubiaur et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
23531488	Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant Knauer, MJ, Girdwood, AJ, Tirona, RG, Kim, RB	Mol. Pharmacol.	2013
10601278	A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters Yang, WP, Wu, Y, Hsiang, B, Sasseville, V, Kirchgessner, TG, Wang, Z, Zhu, Y	J Biol Chem	1999
24799396	Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions Norén, A, Vildhede, A, Wisniewski, JR, Karlgren, M, Svedberg, EK, Lai, Y, Artursson, P	Drug Metab Dispos	2014
21278621	Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity Suzuki, A, Ho, RH, Leake, BF, Mokrab, Y, Meyer zu Schwabedissen, HE, Schwarz, UI, Mizuguchi, K, Tirona, RG, Kim, RB	Pharmacogenet Genomics	2011