Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DEFB1(?-68) [extracellular region]
Stable Identifier
R-HSA-975682
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Beta-defensin 1, DEFB1, DEFB1_HUMAN, hBD-1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Defensins (Homo sapiens)
Beta defensins (Homo sapiens)
Beta-defensins 1, 4A and 103 bind CCR6 (Homo sapiens)
Beta defensins 1,4A,103 [extracellular region] (Homo sapiens)
DEFB1(?-68) [extracellular region] (Homo sapiens)
Beta-defensins 1,4A,103:CCR6 [plasma membrane] (Homo sapiens)
Beta defensins 1,4A,103 [extracellular region] (Homo sapiens)
DEFB1(?-68) [extracellular region] (Homo sapiens)
Beta-defensins are secreted (Homo sapiens)
Beta-defensins [extracellular region] (Homo sapiens)
DEFB1(?-68) [extracellular region] (Homo sapiens)
Beta-defensins bind microbial membranes causing disruption (Homo sapiens)
Beta-defensins [extracellular region] (Homo sapiens)
DEFB1(?-68) [extracellular region] (Homo sapiens)
Beta-defensins:anionic phospholipids [plasma membrane] (Homo sapiens)
Beta-defensins [extracellular region] (Homo sapiens)
DEFB1(?-68) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60022 DEFB1
Gene Names
DEFB1, BD1, HBD1
Chain
signal peptide:1-21, propeptide:22-32, peptide:33-68
Reference Genes
BioGPS Gene:1672 DEFB1
COSMIC (genes):DEFB1 DEFB1
CTD Gene:1672 DEFB1
dbSNP Gene:1672 DEFB1
ENSEMBL:ENSG00000164825 DEFB1
HGNC:2766 DEFB1
KEGG:hsa:1672 DEFB1
Monarch:1672 DEFB1
NCBI Gene:1672 DEFB1
OMIM:602056 DEFB1
UCSC:P60022 DEFB1
Reference Transcript
RefSeq:NM_005218.3 DEFB1
Other Identifiers
11723845_a_at
11723846_at
1672
17074296
210397_PM_at
210397_at
3122686
3122687
3122688
3122692
3122693
39660_at
8149097
GE60155
GO:0002227
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005796
GO:0006935
GO:0006952
GO:0006955
GO:0007186
GO:0009617
GO:0016020
GO:0019722
GO:0019731
GO:0022414
GO:0031731
GO:0042742
GO:0042802
GO:0043226
GO:0045087
GO:0050829
GO:0050830
GO:0060474
GO:0061844
GO:0070062
GO:0097225
GO:0098542
GO:1990742
HMNXSV003019613
ILMN_1686573
TC08000906.hg
X92744_at
g1755147_3p_at
Participates
as a member of
Beta defensins 1,4A,103 [extracellular region] (Homo sapiens)
as a candidate of
Beta-defensins [extracellular region] (Homo sapiens)
Other forms of this molecule
DEFB1(?-68) [Golgi lumen]
DEFB1(1-68) [Golgi lumen]
Inferred To
DEFB1(?-68) [extracellular region]
(Bos taurus)
AvBD14 [extracellular region]
(Gallus gallus)
DEFB1 [extracellular region]
(Sus scrofa)
CBD1 [extracellular region]
(Canis familiaris)
Defb1 [extracellular region]
(Mus musculus)
Defb1 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_005209.1
ENSEMBL
ENSP00000297439
,
ENST00000297439
,
ENST00000642865
,
ENSP00000494448
OpenTargets
ENSG00000164825
HPA
ENSG00000164825-DEFB1
PRO
P60022
Pharos - Targets
P60022
PDB
2NLP
,
2NLQ
,
1IJV
,
1IJU
,
1KJ5
,
2NLS
,
2NLH
,
2NLC
,
2NLB
,
2PLZ
,
2NLD
,
2NLG
,
2NLE
,
2NLF
,
1E4S
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60551 NMT2
1
NMT2 [cytosol]
(R-HSA-184377)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text