SARS-CoV-1 S binds SFTPD 12mer

Stable Identifier
R-HSA-9756603
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
extracellular region
ReviewStatus
5/5
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SARS-CoV-1 S binds SFTPD 12mer
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The pulmonary surfactant protein D (SP-D or SFTPD) binds to to the spike glycoprotein (S) of SARS-CoV-1 (Leth-Larsen R et al. 2007). SARS-CoV-1 S and SARS-CoV-2 S share 76% sequence identity and 86% sequence similarity with SARS-CoV-2 (Mohammed MEA 2021). Based on studies with the SARS-CoV-2 S protein, SFTPD inhibits binding of S to angiotensin-converting enzyme 2 (ACE2) receptor and prevents the virus entry and replication in human cells (Hsieh MH et al. 2021; Arroyo R et al. 2021).
Literature References
PubMed ID Title Journal Year
17412287 The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages

Leth-Larsen, R, Zhong, F, Chow, VT, Lu, J, Holmskov, U

Immunobiology 2007
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Shamovsky, V  (2020-06-25)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Shamovsky, V  (2021-10-15)
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