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CREBBP [cytosol]
Stable Identifier
R-HSA-9756493
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CREB-binding protein, CBP_HUMAN, KAT3A
Locations in the PathwayBrowser for interactor UniProt:Q9Y463 DYR1B
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
CREBBP acetylates SARS-CoV-2 N at K375 (Homo sapiens)
CREBBP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92793 CREBBP
Gene Names
CREBBP, CBP
Chain
initiator methionine:, chain:2-2442
Reference Genes
BioGPS Gene:1387 CREBBP
COSMIC (genes):CREBBP CREBBP
CTD Gene:1387 CREBBP
dbSNP Gene:1387 CREBBP
ENSEMBL:ENSG00000005339 CREBBP
ENSEMBL_homo_sapiens_GENE:ENSG00000005339.15 CREBBP
HGNC:2348 CREBBP
KEGG Gene (Homo sapiens):1387 CREBBP
Monarch:1387 CREBBP
NCBI Gene:1387 CREBBP
OMIM:600140 CREBBP
UCSC:Q92793 CREBBP
Reference Transcript
RefSeq:NM_001079846.1 CREBBP
RefSeq:NM_004380.2 CREBBP
Other Identifiers
11723893_s_at
11740647_a_at
11754200_a_at
11758105_s_at
11758635_s_at
1387
16823433
202160_PM_at
202160_at
211808_PM_s_at
211808_s_at
228177_PM_at
228177_at
33831_at
3677790
3677796
3677797
3677798
3677799
3677800
3677801
3677802
3677803
3677804
3677805
3677806
3677807
3677809
3677810
3677811
3677813
3677814
3677817
3677819
3677821
3677823
3677824
3677825
3677826
3677827
3677832
3677834
3677835
3677841
3677844
3677846
3677847
3677848
3677853
3677854
3677856
3677858
3677860
3677861
3677862
3677863
3677864
3677865
3677870
3677879
3677887
3677888
3677889
3677890
3904613
46099_at
7999044
A_23_P163850
A_24_P322025
A_24_P342279
A_33_P3240229
GE63206
GO:0000122
GO:0000123
GO:0000785
GO:0001223
GO:0001666
GO:0002039
GO:0002223
GO:0002376
GO:0003677
GO:0003682
GO:0003684
GO:0003712
GO:0003713
GO:0003714
GO:0003824
GO:0004402
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006473
GO:0007165
GO:0008270
GO:0008589
GO:0016407
GO:0016479
GO:0016573
GO:0016604
GO:0016740
GO:0016746
GO:0018076
GO:0023052
GO:0030511
GO:0031490
GO:0031648
GO:0031669
GO:0034212
GO:0034644
GO:0036211
GO:0038061
GO:0042592
GO:0042733
GO:0043226
GO:0043426
GO:0043993
GO:0044017
GO:0044877
GO:0045893
GO:0045944
GO:0046872
GO:0048511
GO:0048856
GO:0050896
GO:0051604
GO:0061629
GO:0061733
GO:0065003
GO:0098542
GO:0140096
GO:0140110
GO:0140297
GO:1900034
GO:1900182
HMNXSV003016495
Hs.283860.0.S1_3p_s_at
Hs.55153.0.A1_3p_at
ILMN_1809583
ILMN_2293692
PH_hs_0023345
TC16000823.hg
U89355_at
g4433815_3p_a_at
g4758055_3p_at
Other forms of this molecule
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
FOXO4-S-S-CREBBP [nucleoplasm]
CREBBP [nucleoplasm]
Cross References
RefSeq
NP_004371.2
,
NP_001073315.1
Guide to Pharmacology - Targets
2734
OpenTargets
ENSG00000005339
ZINC - Substances
CBP_HUMAN
ZINC target
Q92793
PRO
Q92793
PDB
6AY5
,
5LPJ
,
5I83
,
5DBM
,
5JEM
,
4N4F
,
4TQN
,
8GA2
,
3P1C
,
4NR5
,
6YIK
,
6FRF
,
5KTU
,
6LQX
,
5SVH
,
1WO4
,
4NR4
,
5W0Q
,
5GH9
,
5I89
,
8FXO
,
8FUP
,
5NRW
,
2LXT
,
5MQK
,
1WO3
,
6DMK
,
5NU3
,
7RLE
,
5I8G
,
5EP7
,
5MPN
,
6M64
,
5XXH
,
7TBH
,
3P1E
,
7JUO
,
5I8B
,
4NYX
,
6ES7
,
1WO7
,
8FXE
,
5MPK
,
2L85
,
7CO1
,
5MQE
,
5W0E
,
5J0D
,
5EIC
,
6YIL
,
6AXQ
,
6QST
,
6SQE
,
4N3W
,
7JFM
,
6FQO
,
4OUF
,
7JFL
,
5ENG
,
4WHU
,
5I86
,
6AY3
,
8HAM
,
5KTX
,
6FQU
,
3P1F
,
6SQM
,
4NYV
,
5NLK
,
8FXA
,
2LXS
,
6FR0
,
3P1D
,
5H85
,
4NR6
,
4A9K
,
4TS8
,
6ALB
,
5KTW
,
5OWK
,
6YIJ
,
1WO6
,
2L84
,
3DWY
,
7XHE
,
1WO5
,
5MPZ
,
7XNE
,
4YK0
,
3SVH
,
8FV2
,
7TB3
,
5CGP
,
5W0L
,
1RDT
,
5MMG
,
7KPY
,
7UGL
,
1LIQ
,
6ES6
,
2RNY
,
2KWF
,
5MQG
,
5MME
,
5W0F
,
2D82
,
5TB6
,
8G6T
,
7EVJ
,
7XH6
,
7XIJ
,
6ALC
,
8FXN
,
4NYW
,
6SXX
,
2KJE
,
6YIM
,
6SQF
,
6ES5
,
8HAL
,
7UGE
,
5LPL
,
1JSP
,
7WX2
,
7XI0
,
4NR7
,
7XM7
,
2N1A
,
8HAN
,
1ZOQ
,
7XNG
,
6FQT
GeneCards
Q92793
HPA
ENSG00000005339-CREBBP
Ensembl
ENST00000262367
,
ENSP00000371502
,
ENSG00000005339
,
ENSP00000262367
,
ENST00000382070
Pharos - Targets
Q92793
ZINC - Predictions - Purchasable
CBP_HUMAN
Orphanet
15801
HMDB Protein
HMDBP00014
Interactors (46)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.96
17
UniProt:Q14653 IRF3
6
p-5S,T404-IRF3 [nucleoplasm]
(R-HSA-936418)
p-4S,T404-IRF3 [nucleoplasm]
(R-HSA-177654)
p-4S,T404-IRF3 [cytosol]
(R-HSA-166258)
IRF3(272-427) [cytosol]
(R-HSA-9729737)
IRF3(2-271) [cytosol]
(R-HSA-9729696)
IRF3 [cytosol]
(R-HSA-166251)
0.929
12
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.757
6
UniProt:P03259 E1A
0.743
5
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.725
5
UniProt:Q6ZUJ4 CC062
0.671
6
UniProt:Q15788 NCOA1
3
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.669
4
UniProt:P03255 E1A
0.656
3
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.656
4
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.628
3
UniProt:Q13568 IRF5
3
p-S446-IRF5 [nucleoplasm]
(R-HSA-9860304)
p-S446-IRF5 [cytosol]
(R-HSA-9860271)
IRF5 [cytosol]
(R-HSA-1015676)
0.618
3
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.618
6
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.609
2
UniProt:P03259-2
0.602
3
UniProt:P55209 NP1L1
0.593
3
UniProt:P16220 CREB1
0.589
2
UniProt:P48551 IFNAR2
0.576
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.573
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.573
2
UniProt:P23769 GATA2
1
GATA2 [nucleoplasm]
(R-HSA-996735)
0.571
2
UniProt:Q14686 NCOA6
1
NCOA6 [nucleoplasm]
(R-HSA-376414)
0.564
2
UniProt:O43524 FOXO3
11
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
FOXO3 [cytosol]
(R-HSA-5687032)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841824)
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841849)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
FOXO3 [nucleoplasm]
(R-HSA-199305)
0.564
3
UniProt:Q12778 FOXO1
5
p-S218-FOXO1 [nucleoplasm]
(R-HSA-5692651)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
0.564
3
IntAct:EBI-15697717 P53K382AC
0.558
2
UniProt:P10242 MYB
1
MYB [nucleoplasm]
(R-HSA-992697)
0.536
2
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.528
3
UniProt:Q9Y6Q9 NCOA3
2
NCOA3 [nucleoplasm]
(R-HSA-442488)
p-S857 NCOA3 [nucleoplasm]
(R-HSA-5687005)
0.527
12
IntAct:EBI-1566585 IL8
0.527
2
UniProt:Q9Y463 DYR1B
0.527
2
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.527
2
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.527
2
UniProt:P29279 CTGF
1
CTGF [extracellular region]
(R-HSA-561148)
0.527
2
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.527
3
UniProt:P52630 STAT2
4
p-Y690-STAT2 [cytosol]
(R-HSA-909683)
STAT2 [cytosol]
(R-HSA-882029)
p-Y690-STAT2 [nucleoplasm]
(R-HSA-909673)
p-Y-STAT2 [cytosol]
(R-HSA-8987235)
0.527
2
ChEBI:83406 MS-417
0.525
2
UniProt:Q9UL17 TBX21
0.524
4
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.504
9
UniProt:P03070 LT
0.499
3
UniProt:P36956-1 SREBF1
5
SREBF1-1 [endoplasmic reticulum membrane]
(R-HSA-1655757)
SREBF1-1 [Golgi membrane]
(R-HSA-1655753)
SREBF1-1(1-530) [Golgi membrane]
(R-HSA-1655718)
SREBF1-1(1-490) [cytosol]
(R-HSA-1655764)
SREBF1-1(1-490) [nucleoplasm]
(R-HSA-1655755)
0.499
3
UniProt:Q12772 SREBF2
5
SREBF2(1-1141) [Golgi membrane]
(R-HSA-1655747)
SREBF2(1-522) [Golgi membrane]
(R-HSA-1655752)
SREBF2(1-484) [cytosol]
(R-HSA-1655723)
SREBF2(1-1141) [endoplasmic reticulum membrane]
(R-HSA-1655733)
SREBF2(1-484) [nucleoplasm]
(R-HSA-1655745)
0.499
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.499
3
UniProt:P36956-3 SREBF1
5
SREBF1-3 [nucleoplasm]
(R-HSA-1655716)
SREBF1-3 [endoplasmic reticulum membrane]
(R-HSA-1655761)
SREBF1-3 [Golgi membrane]
(R-HSA-1655760)
SREBF1-3 [Golgi membrane]
(R-HSA-1655724)
SREBF1-3 [cytosol]
(R-HSA-1655721)
0.499
2
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.499
2
UniProt:P04608 tat
1
Tat (P04608) [nucleoplasm]
(R-HIV-175856)
0.499
2
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.483
2
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.483
2
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