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atROL binds to RBP2
Stable Identifier
R-HSA-975633
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
Synonyms
Membrane retinol binds to cytosolic RBP2
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
atROL binds to RBP2 (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
atROL binds to RBP2 (Homo sapiens)
General
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In enterocytes, the dominant retinol-binding protein is RBP2 (CRBPII) which is abundant and binds retinol faster than the cell membrane. So, even though lipophilic retinol can easily enter the cell membrane of bowel enterocytes, it is collected by the abundancy of RBP2 into the enterocyte cytosol where it is further processed (Inagami & Ong 1997).
Literature References
PubMed ID
Title
Journal
Year
1542003
Purification and partial characterization of cellular retinol-binding protein, type two, from human small intestine
Ong, DE
,
Inagami, S
J Nutr
1992
Participants
Input
atROL [plasma membrane]
RBP2 [cytosol]
(Homo sapiens)
Output
RBP2:atROL [cytosol]
(Homo sapiens)
Participates
as an event of
Retinoid metabolism and transport (Homo sapiens)
Orthologous Events
atROL binds to RBP2 (Bos taurus)
atROL binds to RBP2 (Caenorhabditis elegans)
atROL binds to RBP2 (Canis familiaris)
atROL binds to RBP2 (Danio rerio)
atROL binds to RBP2 (Drosophila melanogaster)
atROL binds to RBP2 (Gallus gallus)
atROL binds to RBP2 (Mus musculus)
atROL binds to RBP2 (Rattus norvegicus)
atROL binds to RBP2 (Sus scrofa)
atROL binds to RBP2 (Xenopus tropicalis)
Authored
Stephan, R (2010-09-19)
Reviewed
D'Eustachio, P (2010-11-09)
Created
Jassal, B (2010-10-01)
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