CYP3A4 monooxygenates ATV to 2-OH-ATV

Stable Identifier
R-HSA-9756169
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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CYP3A4 monooxygenates ATV to 2-OH-ATV
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Atorvastatin (ATV) is hydroxylated to hydroxy-metabolites, predominantly by cytochrome P450 3A4 (CYP3A4) (Fujino et al. 2004, Park et al. 2008). Here, ATV hydroxylation to 2-hydroxyatorvastatin (2-OH-ATV, aka ortho-hydroxyatorvastatin) is described.
Literature References
PubMed ID Title Journal Year
18720283 Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin

Park, JE, Kim, KB, Moon, BS, Shin, JG, Bae, SK, Liu, KH

Xenobiotica 2008
15801541 Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors

Fujino, H, Sakaeda, T, Saito, T, Tsunenari, Y, Kojima, J

Xenobiotica 2004
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Output
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as an event of
Catalyst Activity

monooxygenase activity of CYP3A4 [endoplasmic reticulum membrane]

Physical Entity
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)
Authored
Jassal, B  (2021-10-12)
Reviewed
Huddart, R  (2022-03-01)
Created
Jassal, B  (2021-10-12)
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