CYP3A4 monooxygenates ATV to 2-OH-ATV

Stable Identifier
R-HSA-9756169
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Atorvastatin (ATV) is hydroxylated to hydroxy-metabolites, predominantly by cytochrome P450 3A4 (CYP3A4) (Fujino et al. 2004, Park et al. 2008). Here, ATV hydroxylation to 2-hydroxyatorvastatin (2-OH-ATV, aka ortho-hydroxyatorvastatin) is described.
Literature References
PubMed ID Title Journal Year
18720283 Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin

Park, JE, Kim, KB, Moon, BS, Shin, JG, Bae, SK, Liu, KH

Xenobiotica 2008
15801541 Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors

Fujino, H, Sakaeda, T, Saito, T, Tsunenari, Y, Kojima, J

Xenobiotica 2004
Participants
Participates
Catalyst Activity

monooxygenase activity of CYP3A4 [endoplasmic reticulum membrane]

Orthologous Events
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