Reactions specific to the hybrid N-glycan synthesis pathway

Stable Identifier
R-HSA-975574
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Reactions specific to the hybrid N-glycan synthesis pathway
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The transfer of a bisecting GlcNAc by MGAT3 commits the pathway toward the synthesis of hybrid glycans, because MAN2 is not able to operate on bisected oligosaccharides (Schachter et al 2000, Priatel JJ et al, 1997). The expression of MGAT3 over MGAT2 in a tissue can regulate the synthesis of hybrid toward complex N-glycans. The addition of a GlcNAc between the two arms also prevents the action of MGAT4, MGAT5 and FUT8.
Literature References
PubMed ID Title Journal Year
11421343 The joys of HexNAc. The synthesis and function of N- and O-glycan branches

Schachter, H

Glycoconj J 2000
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Orthologous Events
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Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-11-18)
Created
Jassal, B  (2010-09-30)
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