Reactome | SKP2 [nucleoplasm]

SKP2 [nucleoplasm]

Stable Identifier

R-HSA-975554

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

S-phase kinase-associated protein 2, SKP2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q12834 CDC20

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External Reference Information

External Reference

UniProt:Q13309 SKP2

Gene Names

SKP2, FBXL1

Chain

chain:1-424

Reference Genes

BioGPS Gene:6502 SKP2

COSMIC (genes):SKP2 SKP2

CTD Gene:6502 SKP2

dbSNP Gene:6502 SKP2

ENSEMBL:ENSG00000145604 SKP2

ENSEMBL_homo_sapiens_GENE:ENSG00000145604.17 SKP2

HGNC:10901 SKP2

KEGG Gene (Homo sapiens):6502 SKP2

Monarch:6502 SKP2

NCBI Gene:6502 SKP2

OMIM:601436 SKP2

UCSC:Q13309 SKP2

Reference Transcript

Other Identifiers

11739144_a_at

11760241_a_at

16984032

1941_at

203625_PM_x_at

203625_x_at

203626_PM_s_at

203626_s_at

210567_PM_s_at

210567_s_at

211042_PM_x_at

211042_x_at

2651085

2806519

2806520

2806522

2806523

2806528

2806529

2806530

2806531

2806532

2806534

2806536

2806544

2806545

2806546

43055_at

6502

8104912

A_14_P134273

A_23_P156310

GE59094

GO:0000082

GO:0000086

GO:0000209

GO:0000278

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006511

GO:0012501

GO:0016567

GO:0019005

GO:0023052

GO:0030163

GO:0031146

GO:0033148

GO:0036211

GO:0042802

GO:0042981

GO:0043161

GO:0043226

GO:0045087

GO:0051607

GO:0051726

GO:0070936

GO:0098542

GO:1902916

HMNXSV003042493

ILMN_1665538

ILMN_1791002

ILMN_1801391

PH_hs_0002055

PH_hs_0035392

TC05000161.hg

U33761_at

g12655170_3p_a_at

g12655170_3p_s_at

g5174684_3p_a_at

Participates

as a component of

as an input of

Other forms of this molecule

SKP2 [cytosol]

PolyUb-SKP2 [nucleoplasm]

Inferred To

Skp2 [nucleoplasm] (Drosophila melanogaster)

Skp2 [nucleoplasm] (Mus musculus)

Skp2 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of SKP2 [nucleoplasm] (Canis familiaris)

Ghost homologue of SKP2 [nucleoplasm] (Danio rerio)

Ghost homologue of SKP2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of SKP2 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of SKP2 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of SKP2 [nucleoplasm] (Xenopus tropicalis)

SKP2 [nucleoplasm] (Bos taurus)

SKP2 [nucleoplasm] (Gallus gallus)

SKP2 [nucleoplasm] (Sus scrofa)

skpt-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001230049.1, NP_005974.2, NP_116026.1

Guide to Pharmacology - Targets

3235

OpenTargets

ENSG00000145604

HPA

ENSG00000145604-SKP2

GeneCards

Q13309

Ensembl

ENST00000274254, ENST00000274255, ENSP00000274255, ENSG00000145604, ENSP00000274254

PRO

Q13309

Pharos - Targets

Q13309

PDB

8BYL, 7B5M, 8CDJ, 8OR0, 8OR3, 7LUO, 1FQV, 8BYA, 1FS1, 2ASS, 7ZBZ, 7Z8T, 7Z8V, 1LDK, 8CDK, 2AST, 8OR4, 1FS2, 7B5L, 7B5R, 7ZBW

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.952	18
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.892	12
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.858	9
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.823	15
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.75	4
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.731	4
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.725	7
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.725	6
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.725	6
UniProt:Q00526 CDK3			0.643	4
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.623	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	4
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.591	3
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.576	3
UniProt:Q9NTG7 SIRT3	2	SIRT3 [nucleoplasm] (R-HSA-9622879) SIRT3(?-399) [mitochondrial matrix] (R-HSA-1605416)	0.576	5
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.564	4
UniProt:Q6DN90 IQEC1			0.527	3
UniProt:Q9UBW8 COPS7A	2	COPS7A [nucleoplasm] (R-HSA-5697011) COPS7A [cytosol] (R-HSA-416964)	0.527	2
UniProt:P12268 IMPDH2	4	IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330) IMPDH2 [cytosol] (R-HSA-57350)	0.527	2
UniProt:Q9H9A6 LRC40			0.527	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.527	2
UniProt:Q2VPB7 AP5B1			0.527	3
UniProt:Q5VUJ6 LRCH2			0.527	2
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	3
UniProt:P0CI25 TRI49			0.527	2
UniProt:O14531 DPYSL4	3	p-Y-DPYSL4 [cytosol] (R-HSA-399794) DPYSL4 [cytosol] (R-HSA-398126) p-S544-DPYSL4 [cytosol] (R-HSA-399808)	0.527	2
UniProt:Q96BY7 ATG2B			0.527	2
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.527	3
UniProt:Q9BZL6 PRKD2	1	PRKD2 [cytosol] (R-HSA-58214)	0.527	2
UniProt:Q6ZRV2 FA83H			0.527	3
UniProt:Q8N5M4 TTC9C			0.527	4
UniProt:Q9BV68 RNF126	1	RNF126 [cytosol] (R-HSA-8851642)	0.527	2
UniProt:Q6PJI9 WDR59	1	WDR59 [lysosomal membrane] (R-HSA-9638236)	0.527	3
UniProt:Q6SPF0 SAMD1			0.527	3
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	3
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274)	0.527	2
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.527	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.527	2
UniProt:Q4AE16 Q4AE16			0.524	3
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.524	3
UniProt:P09803 Cdh1	6	CDH1(155-700) [plasma membrane] (R-MMU-2534244) CDH1(701-882) [extracellular region] (R-MMU-2534158) Cdh1(157-884) [plasma membrane] (R-MMU-199081) CDH1(155-750) [plasma membrane] (R-MMU-202940) CDH1(751-882) [plasma membrane] (R-MMU-202929) CDH1(155-882) [plasma membrane] (R-MMU-198003)	0.524	2
UniProt:Q13415 ORC1	5	ORC1 [nucleoplasm] (R-HSA-68522) ORC1 [cytosol] (R-HSA-113840) p-S,T-ORC1 [nucleoplasm] (R-HSA-68943) PolyUb,p-S,T-ORC1 [nucleoplasm] (R-HSA-9032189) PolyUb,p-S,T-ORC1 [cytosol] (R-HSA-9032195)	0.524	2

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