SARS-CoV-2 8:class I MHC binds BECN1

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
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SARS-CoV-2 ORF8 (8), which has no orthologous protein in SARS-CoV-1 (Li T et al. 2020), was found to regulate the expression of class I MHC on the surface of the infected cells through an autophagy-dependent lysosomal degradation of class I MHC (Zhang Y et al. 2021). Viral 8 co-localized and co-immunoprecipitated with Beclin 1 (BECN1) upon coexpression of tagged proteins in human embryonic kidney 293T (HEK293T) cells. SARS-CoV-2 8 failed to induce class I MHC degradation in BECN1-deficient cells (Zhang Y et al. 2021). The data suggest that 8 (ORF8) induces BECN1-dependent autophagy to degrade class I MHC (Zhang Y et al. 2021).
Literature References
PubMed ID Title Journal Year
34021074 The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Zhang, X, Song, Z, Liu, J, Yuan, Y, Li, Y, Liu, B, Wu, L, Li, R, Xiao, F, Chen, J, Zhang, H, Pan, T, He, X, Yu, F, Ma, X, Luo, B, Huang, W, Xia, B, Zhang, Y, Huang, F, Zhang, J, Chen, Y, Yan, S, Yang, T

Proc Natl Acad Sci U S A 2021
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
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