Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-T177-CDK6:CCND2 [nucleoplasm]
Stable Identifier
R-HSA-9755190
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cyclin D2:p-T177-Cdk6 complex
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2:CDK6 inhibitors (CCND2) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
Drug-mediated inhibition of CDK4/CDK6 activity (Homo sapiens)
CDK6 inhibitors bind CDK6 (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2:CDK6 inhibitors (CCND2) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T177-CDK6:CCND2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
8114739
Identification of G1 kinase activity for cdk6, a novel cyclin D partner
Meyerson, M
,
Harlow, E
Mol. Cell. Biol.
1994
Participants
components
CCND2 [nucleoplasm]
(Homo sapiens)
p-T177-CDK6 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
p-T177-CDK6:CCND2:CDK6 inhibitors (CCND2) [nucleoplasm] (Homo sapiens)
as a member of
p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Inferred To
p-T177-CDK6:CCND2 [nucleoplasm]
(Bos taurus)
p-T177-CDK6:CCND2 [nucleoplasm]
(Canis familiaris)
p-T177-CDK6:CCND2 [nucleoplasm]
(Drosophila melanogaster)
p-T177-CDK6:CCND2 [nucleoplasm]
(Gallus gallus)
p-T177-CDK6:CCND2 [nucleoplasm]
(Mus musculus)
p-T177-CDK6:CCND2 [nucleoplasm]
(Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm]
(Schizosaccharomyces pombe)
p-T177-CDK6:CCND2 [nucleoplasm]
(Sus scrofa)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text