Reactome | SLC29A1 transports RBV from cytosol to extracellular region

SLC29A1 transports RBV from cytosol to extracellular region

Stable Identifier

R-HSA-9755035

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

Synonyms

SLC29A1 exports RBV

ReviewStatus

5/5

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SLC29A1 transports RBV from cytosol to extracellular region

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Equilibrative nucleoside transporters are located on both sides of epithelial cells and are essential to the export of ribavirin (RBV) out of cells. They cannot transport the phosphorylated RBV analogs RBV-MP, RBV-DP, and RBV-TP (Podgorska et al, 2005; Errasti-Murugarren and Pastor-Anglada, 2010). Efflux pumps are not involved in RBV export (Karbanova et al, 2019).

Literature References

PubMed ID	Title	Journal	Year
20096989	Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes Yamaguchi, M, Sugawara, M, Tero, A, Kikukawa, T, Yamamoto, T, Miyauchi, S, Nakagaki, T, Takagi, S	Biophys Chem	2010
20504255	Drug transporter pharmacogenetics in nucleoside-based therapies Pastor-Anglada, M, Errasti-Murugarren, E	Pharmacogenomics	2010
16265592	Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters Pawelczyk, T, Kocbuch, K, Podgorska, M	Acta Biochim Pol	2005
30716294	Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters Staud, F, Ceckova, M, Karahoda, R, Karbanova, S, Jiraskova, L, Cerveny, L, Ptackova, Z	Biochem Pharmacol	2019