Reactome | SLC29A1 transports RBV from extracellular region to cytosol

SLC29A1 transports RBV from extracellular region to cytosol

Stable Identifier

R-HSA-9755015

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

SLC29A1 imports RBV

ReviewStatus

5/5

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SLC29A1 transports RBV from extracellular region to cytosol

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The equilibrative nucleoside transporter 1 (ENT1, SLC29A1) is directly involved in the transport of ribavirin (RBV) into cells, although a molecular mechanism has not been defined. It is possible that the observed dependency of RBV uptake on the presence of SLC29A1 is mediated by its binding to SLC28C2,3 (Yamamoto et al, 2010; Fukuchi et al, 2010). The role of equilibrative nucleoside transporter 2 (ENT2, SLC29A2) seems to be minor, at least in placental cells (Owen et al, 2005; Govindajaran et al, 2008; Nishimura et al, 2019). As both concentrative and equilibrative transporters are ubiquitously expressed, RBV may be absorbed extensively (Jarvis et al, 1998; Errasti-Murugarren and Pastor-Anglada, 2010).

Literature References

PubMed ID	Title	Journal	Year
20096989	Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes Yamaguchi, M, Sugawara, M, Tero, A, Kikukawa, T, Yamamoto, T, Miyauchi, S, Nakagaki, T, Takagi, S	Biophys Chem	2010
20504255	Drug transporter pharmacogenetics in nucleoside-based therapies Pastor-Anglada, M, Errasti-Murugarren, E	Pharmacogenomics	2010
15861032	Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2 Carlson, EJ, Stryke, D, Giacomini, KM, Owen, RP, Kawamoto, M, Ferrin, TE, Johns, SJ, Gray, JH, Taylor, TR, Huang, CC	Pharmacogenet Genomics	2005
9605565	Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)-nucleoside transporters Glue, P, Jarvis, SM, Thorn, JA	Br J Pharmacol	1998
31520644	Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake Tachikawa, M, Sano, Y, Tomi, M, Nishimura, T, Nakashima, E, Katakura, S, Takahashi, Y, Takagi, A, Maruyama, T, Terasaki, T, Tanaka, T, Noguchi, S, Uchida, Y	J Pharm Sci	2019
18635603	Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes Pastor-Anglada, M, Whittington, D, LeCluyse, E, Endres, CJ, Unadkat, JD, Govindarajan, R, Tse, CM	Am J Physiol Gastrointest Liver Physiol	2008
30716294	Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters Staud, F, Ceckova, M, Karahoda, R, Karbanova, S, Jiraskova, L, Cerveny, L, Ptackova, Z	Biochem Pharmacol	2019