SLC29A1 transports RBV from extracellular region to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
SLC29A1 imports RBV
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The equilibrative nucleoside transporter 1 (ENT1, SLC29A1) is directly involved in the transport of ribavirin (RBV) into cells, although a molecular mechanism has not been defined. It is possible that the observed dependency of RBV uptake on the presence of SLC29A1 is mediated by its binding to SLC28C2,3 (Yamamoto et al, 2010; Fukuchi et al, 2010). The role of equilibrative nucleoside transporter 2 (ENT2, SLC29A2) seems to be minor, at least in placental cells (Owen et al, 2005; Govindajaran et al, 2008; Nishimura et al, 2019). As both concentrative and equilibrative transporters are ubiquitously expressed, RBV may be absorbed extensively (Jarvis et al, 1998; Errasti-Murugarren and Pastor-Anglada, 2010).
Literature References
PubMed ID Title Journal Year
20096989 Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes

Yamaguchi, M, Sugawara, M, Tero, A, Kikukawa, T, Yamamoto, T, Miyauchi, S, Nakagaki, T, Takagi, S

Biophys Chem 2010
20504255 Drug transporter pharmacogenetics in nucleoside-based therapies

Pastor-Anglada, M, Errasti-Murugarren, E

Pharmacogenomics 2010
15861032 Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2

Carlson, EJ, Stryke, D, Giacomini, KM, Owen, RP, Kawamoto, M, Ferrin, TE, Johns, SJ, Gray, JH, Taylor, TR, Huang, CC

Pharmacogenet Genomics 2005
9605565 Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)-nucleoside transporters

Glue, P, Jarvis, SM, Thorn, JA

Br J Pharmacol 1998
31520644 Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake

Tachikawa, M, Sano, Y, Tomi, M, Nishimura, T, Nakashima, E, Katakura, S, Takahashi, Y, Takagi, A, Maruyama, T, Terasaki, T, Tanaka, T, Noguchi, S, Uchida, Y

J Pharm Sci 2019
18635603 Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes

Pastor-Anglada, M, Whittington, D, LeCluyse, E, Endres, CJ, Unadkat, JD, Govindarajan, R, Tse, CM

Am J Physiol Gastrointest Liver Physiol 2008
30716294 Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters

Staud, F, Ceckova, M, Karahoda, R, Karbanova, S, Jiraskova, L, Cerveny, L, Ptackova, Z

Biochem Pharmacol 2019
Catalyst Activity

nucleoside transmembrane transporter activity of SLC29A1 [plasma membrane]

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