Reactome | NME1,2 hexamers phosphorylate RBV-DP

NME1,2 hexamers phosphorylate RBV-DP

Stable Identifier

R-HSA-9755013

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Both nucleoside diphosphate kinases A and B (NME1, NME2) hexamers phosphorylate ribavirin diphosphate (RBV-DP) to the triphosphate (RBV-TP) (Bourdais et al, 1996; Gallois-Montbrun et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
12606760	Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets Gallois-Montbrun, S, Chen, Y, Dutartre, H, Sophys, M, Moréra, S, Guerreiro, C, Schneider, B, Mulard, L, Janin, J, Veron, M, Deville-Bonne, D, Canard, B	Mol Pharmacol	2003
8626464	Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase Bourdais, J, Biondi, R, Sarfati, S, Guerreiro, C, Lascu, I, Janin, J, Véron, M	J Biol Chem	1996