Unknown kinase phosphorylates RBV-MP

Stable Identifier
R-HSA-9754978
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
RBV-MP is phosphorylated
ReviewStatus
5/5
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Ribavirin diphosphate (RBV-DP) is the intermediate of ribavirin (RBV) activation by phosphorylation, and it is found in cells treated with RBV (Miller et al, 1977; Glue 1999). The enzyme responsible for phosphorylation of the monophosphate is not known. A possible candidate would be cytosolic guanylate kinase 1 (GUK1) which is known to activate carbovir, 6-mercaptopurine and other drugs (see e.g. Miller et al, 1977; Miller et al, 1992 about these activities).
Literature References
PubMed ID Title Journal Year
1383219 Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity

Miller, WH, Boyd, FL, Miller, RL, Hopkins, S, Garvey, EP, Reardon, JE, Daluge, SM

J Biol Chem 1992
197968 Reassessment of the interactions of guanylate kinase and 6-thioguanosine 5'-phosphate

Spector, T, Miller, RL, Adamczyk, DL

Biochem Pharmacol 1977
280136 The relationship between the metabolism of ribavirin and its proposed mechanism of action

Simon, LN, Kigwana, LJ, Roboz, J, Miller, JP, Robins, RK, Streeter, DG

Ann N Y Acad Sci 1977
10349689 The clinical pharmacology of ribavirin

Glue, P

Semin Liver Dis 1999
Participants
Participates
Catalyst Activity

nucleoside monophosphate kinase activity of unknown kinase [cytosol]

Authored
Reviewed
Created
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