ADK phosphorylates RBV

Stable Identifier
R-HSA-9754974
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Adenosine kinase (ADK) takes part in phosphorylation of ribavirin (RBV) in erythrocytes (Page and Connor, 1990). While 5′-nucleotidase (NT5C2) has a catalytic efficiency much better than that of adenosine kinase (ADK), the actual contribution of ADK to RBV phosphorylation depends on the physiological concentrations of enzymes and other effectors, which are unknown (Wu et al, 2005). Phosphorylation to ribavirin monophosphate (RBV-MP) appears to be the rate-limiting step in the intracellular ribavirin metabolism resulting in the triphosphate (Page and Connor, 1990).
Literature References
PubMed ID Title Journal Year
15917509 Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes

Walker, H, Wu, JZ, Shim, JH, Hong, Z, Larson, G

Antimicrob Agents Chemother 2005
2159925 The metabolism of ribavirin in erythrocytes and nucleated cells

Page, T, Connor, JD

Int J Biochem 1990
Participants
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Catalyst Activity

adenosine kinase activity of ADK [cytosol]

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