SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-9754934
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
Synonyms
SLC28C2,3 cotransports RBV and Na+ into cells
ReviewStatus
5/5
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SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol
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The concentrative sodium/nucleoside cotransporters 2 and 3 (CNT2, SLC28A2 and CNT3, SLC28C3) import ribavirin (RBV) together with sodium ions (Na+) into cells. As the transporters are expressed on the plasma membranes of many cell types, RBV may be absorbed extensively (Errasti-Murugarren et al, 2007; Podgorska et al, 2005). Kinetic studies in Xenopus laevis oocytes point to a possible interaction of SLC29A1 with the SLC28A3 transport process (Yamamoto et al, 2010). Presence of interferon-alpha (IFNA) enhances uptake by apparent promotion of SLC28A2 translocation to the plasma membrane (probably by upregulation of SLC28A2 expression), which explains synergistic effects in treatment with both drugs (Pinilla-Macua et al, 2014).
Literature References
PubMed ID Title Journal Year
20096989 Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes

Yamaguchi, M, Sugawara, M, Tero, A, Kikukawa, T, Yamamoto, T, Miyauchi, S, Nakagaki, T, Takagi, S

Biophys Chem 2010
16265592 Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters

Pawelczyk, T, Kocbuch, K, Podgorska, M

Acta Biochim Pol 2005
9647364 Intestinal absorption of ribavirin is preferentially mediated by the Na+-nucleoside purine (N1) transporter

Glue, P, Unadkat, JD, Ngo, LY, Patil, SD

Pharm Res 1998
24957263 Ribavirin uptake into human hepatocyte HHL5 cells is enhanced by interferon-α via up-regulation of the human concentrative nucleoside transporter (hCNT2)

Pastor-Anglada, M, Fernández-Calotti, P, Pérez-Del-Pulgar, S, Pinilla-Macua, I

Mol Pharm 2014
17412768 Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs

Pastor-Anglada, M, Casado, FJ, Errasti-Murugarren, E

J Physiol 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

nucleoside:sodium symporter activity of SLC28A2,3 [plasma membrane]

Physical Entity
SLC28A2,3 [plasma membrane] (Homo sapiens)
Activity
nucleoside:sodium symporter activity (GO:0005415)
Orthologous Events
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Bos taurus)
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Canis familiaris)
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Gallus gallus)
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Mus musculus)
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Sus scrofa)
SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Xenopus tropicalis)
Authored
Stephan, R  (2021-09-20)
Reviewed
Thorn, CF  (2022-06-25)
Created
Stephan, R  (2021-10-05)
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