Reactome | SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol

SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol

Stable Identifier

R-HSA-9754934

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

SLC28C2,3 cotransports RBV and Na+ into cells

ReviewStatus

5/5

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SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol

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The concentrative sodium/nucleoside cotransporters 2 and 3 (CNT2, SLC28A2 and CNT3, SLC28C3) import ribavirin (RBV) together with sodium ions (Na+) into cells. As the transporters are expressed on the plasma membranes of many cell types, RBV may be absorbed extensively (Errasti-Murugarren et al, 2007; Podgorska et al, 2005). Kinetic studies in Xenopus laevis oocytes point to a possible interaction of SLC29A1 with the SLC28A3 transport process (Yamamoto et al, 2010). Presence of interferon-alpha (IFNA) enhances uptake by apparent promotion of SLC28A2 translocation to the plasma membrane (probably by upregulation of SLC28A2 expression), which explains synergistic effects in treatment with both drugs (Pinilla-Macua et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
20096989	Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes Yamamoto, T, Sugawara, M, Kikukawa, T, Miyauchi, S, Yamaguchi, M, Tero, A, Takagi, S, Nakagaki, T	Biophys Chem	2010
16265592	Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters Podgorska, M, Kocbuch, K, Pawelczyk, T	Acta Biochim Pol	2005
9647364	Intestinal absorption of ribavirin is preferentially mediated by the Na+-nucleoside purine (N1) transporter Patil, SD, Ngo, LY, Glue, P, Unadkat, JD	Pharm Res	1998
24957263	Ribavirin uptake into human hepatocyte HHL5 cells is enhanced by interferon-α via up-regulation of the human concentrative nucleoside transporter (hCNT2) Pinilla-Macua, I, Fernández-Calotti, P, Pérez-Del-Pulgar, S, Pastor-Anglada, M	Mol Pharm	2014
17412768	Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs Errasti-Murugarren, E, Pastor-Anglada, M, Casado, FJ	J Physiol	2007