Reactome | NT5C2 tetramer phosphorylates RBV

NT5C2 tetramer phosphorylates RBV

Stable Identifier

R-HSA-9754916

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ribavirin (RBV) phosphorylation to ribavirin monophosphate (RBV-MP) can be catalyzed by the 5′-nucleotidase NT5C2, with a catalytic efficiency much better than that by adenosine kinase (ADK) (Wu et al, 2005). This appears to be the rate-limiting step in the intracellular ribavirin metabolism resulting in the triphosphate (Page and Connor, 1990; Wallden and Nordlund, 2011).

Literature References

PubMed ID	Title	Journal	Year
15917509	Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes Walker, H, Wu, JZ, Shim, JH, Hong, Z, Larson, G	Antimicrob Agents Chemother	2005
2159925	The metabolism of ribavirin in erythrocytes and nucleated cells Page, T, Connor, JD	Int J Biochem	1990
21396942	Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5'-nucleotidase II Nordlund, P, Wallden, K	J Mol Biol	2011