SARS-CoV-2 3a tetramer binds to CAV1

Stable Identifier
R-HSA-9754518
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment, Golgi membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SARS-CoV-2 3a tetramer binds to CAV1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
This SARS-CoV-2 event is manually inferred from the SARS-CoV-1 event of viroporin 3a (ORF3a) interaction with caveolin-1 (CAV1). This assumption is supported by in silico studies of complex formation between SARS-CoV-2 3a and CAV1 (Gupta S et al. 2022).

While located in the ERGIC or Golgi apparatus SARS-CoV-1 3a binds to the regulator and scaffolding protein CAV1 (Padhan K et al. 2007). Through its interaction with CAV1, SARS-CoV-1 3a (ORF3a) protein may regulate virus uptake, as well as the trafficking of structural proteins.

Literature References
PubMed ID Title Journal Year
35126886 D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1

Mukherjee, S, Lee, ST, Gupta, S, Basuchowdhuri, P, Sarkar, S, Banerjee, K, Mallick, D, Jana, SS

Comput Struct Biotechnol J 2022
17947532 Severe acute respiratory syndrome coronavirus Orf3a protein interacts with caveolin

Lee, MY, Hui, PY, Cheung, CY, Peiris, JSM, Hussain, A, Jameel, S, Tanwar, C, Padhan, K

J Gen Virol 2007
Participants
Input
Output
Participates
as an event of
Inferred From
SARS-CoV-1 3a tetramer binds to CAV1 (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Shamovsky, V  (2021-10-27)
Reviewed
Messina, F  (2022-02-18)
Created
Shamovsky, V  (2021-09-28)
Cite Us!