Reactome | GABRR1 [plasma membrane]

GABRR1 [plasma membrane]

Stable Identifier

R-HSA-975442

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma-aminobutyric acid receptor subunit rho-1, GBRR1_HUMAN

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABRR pentamers:GABA transports extracellular Cl- to cytosol (Homo sapiens)
        
        GABRR pentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABRR pentamers [plasma membrane] (Homo sapiens)
        
        GABRR1 pentamer [plasma membrane] (Homo sapiens)
        
        GABRR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24046 GABRR1

Gene Names

GABRR1

Chain

signal peptide:1-21, chain:22-479

Reference Genes

BioGPS Gene:2569 GABRR1

COSMIC (genes):GABRR1 GABRR1

CTD Gene:2569 GABRR1

dbSNP Gene:2569 GABRR1

ENSEMBL:ENSG00000146276 GABRR1

HGNC:4090 GABRR1

KEGG:hsa:2569 GABRR1

Monarch:2569 GABRR1

NCBI Gene:2569 GABRR1

OMIM:137161 GABRR1

UCSC:P24046 GABRR1

Reference Transcript

Other Identifiers

11733526_a_at

11733527_at

11750955_a_at

11750956_x_at

17021557

206525_PM_at

206525_at

2569

2964094

2964095

2964096

2964097

2964098

2964099

2964101

2964102

2964103

2964106

2964108

2964110

2964111

2964114

2964115

2964116

2964118

2964119

2964120

2964123

2964124

33051_at

46020_at

8128087

A_23_P256754

GE58015

GO:0004888

GO:0004890

GO:0005215

GO:0005216

GO:0005230

GO:0005254

GO:0005886

GO:0006811

GO:0006821

GO:0007214

GO:0007268

GO:0016020

GO:0016917

GO:0019904

GO:0022851

GO:0023052

GO:0030594

GO:0034220

GO:0034707

GO:0042734

GO:0042802

GO:0043005

GO:0044877

GO:0045202

GO:0045211

GO:0050804

GO:0055085

GO:0060089

GO:0098978

GO:0098982

GO:0099505

GO:0099507

GO:1902476

GO:1902495

GO:1902711

HMNXSV003013818

ILMN_1760431

M62400_at

PH_hs_0025637

TC06001938.hg

g4503868_3p_at

Participates

as a component of

GABRR1 pentamer [plasma membrane] (Homo sapiens)

Inferred To

GABRR1 [plasma membrane] (Gallus gallus)

GABRR1 [plasma membrane] (Mus musculus)

GABRR1 [plasma membrane] (Rattus norvegicus)

GABRR1 [plasma membrane] (Sus scrofa)

unc-49 [plasma membrane] (Caenorhabditis elegans)

exp-1 [plasma membrane] (Caenorhabditis elegans)

Homologues of GABRR1 [plasma membrane] (Caenorhabditis elegans)

Homologues of GABRR1 [plasma membrane] (Drosophila melanogaster)

lgc-35 [plasma membrane] (Caenorhabditis elegans)

Rdl [plasma membrane] (Drosophila melanogaster)

gabrr1 [plasma membrane] (Xenopus tropicalis)

lgc-38 [plasma membrane] (Caenorhabditis elegans)

Lcch3 [plasma membrane] (Drosophila melanogaster)

lgc-43 [plasma membrane] (Caenorhabditis elegans)

gab-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

ZINC - World Drugs

GBRR1_HUMAN

Guide to Pharmacology - Targets

420

ENSEMBL

ENSP00000394687, ENSP00000358463, ENST00000369451, ENST00000454853, ENSP00000412673, ENST00000435811

OpenTargets

ENSG00000146276

ZINC - FDA approved

GBRR1_HUMAN

ZINC - Substances

GBRR1_HUMAN

ZINC - Biogenic

GBRR1_HUMAN

ZINC target

P24046

PRO

P24046

GlyGen

P24046

PDB

8OQ8, 8OQ7, 8OP9, 8OQ6, 8OQA

ZINC - Investigational

GBRR1_HUMAN

ZINC - Metabolites

GBRR1_HUMAN

HPA

ENSG00000146276-GABRR1

Pharos - Targets

P24046

ZINC - Predictions - Purchasable

GBRR1_HUMAN

HMDB Protein

HMDBP08212