GLRA:GLRB:Gly transports extracellular Cl- to cytosol

Stable Identifier
Homo sapiens
The glycine receptor complex is permeable to Cl- when glycine binds to it
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The glycine receptor (GLR) is a ligand-gated ion channel. It is functional as a heteropentamer, consisting of alpha (GLRA) and beta (GLRB) subunits. With no ligand bound, the receptor complex is closed to chloride ions. Binding of the inhibitory neurotransmitter glycine (Gly) to this receptor complex increases chloride conductance into neurons and thus produces hyperpolarization (inhibition of neuronal firing) (Grenningloh et al. 1990, Nikolic et al. 1998, Handford et al. 1996).

Literature References
PubMed ID Title Journal Year
2155780 Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes

Becker, CM, Grenningloh, G, Schofield, PR, Betz, H, Siddique, T, Schmieden, V, Mohandas, TK, Seeburg, PH

EMBO J 1990
9677400 The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts

Becker, CM, Poustka, A, Laube, B, Nikolic, Z, Lichter, P, M├╝lhardt, C, Weber, RG, Kioschis, P

J Biol Chem 1998
8717357 The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes

Baker, E, Schofield, PR, Sutherland, GR, Handford, CA, Ford, JH, Webb, GC, Lynch, JW

Brain Res Mol Brain Res 1996
Catalyst Activity

extracellularly glycine-gated chloride channel activity of GLRA:GLRB:Gly [plasma membrane]

Orthologous Events
Cross References
Cite Us!