GLRA:GLRB:Gly transports extracellular Cl- to cytosol

Stable Identifier
R-HSA-975389
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
The glycine receptor complex is permeable to Cl- when glycine binds to it
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The glycine receptor (GLR) is a ligand-gated ion channel. It is functional as a heteropentamer, consisting of alpha (GLRA) and beta (GLRB) subunits. With no ligand bound, the receptor complex is closed to chloride ions. Binding of the inhibitory neurotransmitter glycine (Gly) to this receptor complex increases chloride conductance into neurons and thus produces hyperpolarization (inhibition of neuronal firing) (Grenningloh et al. 1990, Nikolic et al. 1998, Handford et al. 1996).

Literature References
PubMed ID Title Journal Year
9677400 The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts

Nikolic, Z, Laube, B, Weber, RG, Lichter, P, Kioschis, P, Poustka, A, M├╝lhardt, C, Becker, CM

J Biol Chem 1998
2155780 Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes

Grenningloh, G, Schmieden, V, Schofield, PR, Seeburg, PH, Siddique, T, Mohandas, TK, Becker, CM, Betz, H

EMBO J 1990
8717357 The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes

Handford, CA, Lynch, JW, Baker, E, Webb, GC, Ford, JH, Sutherland, GR, Schofield, PR

Brain Res Mol Brain Res 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
extracellularly glycine-gated chloride channel activity of GLRA:GLRB:Gly [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
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Created