Reactome | NAT1,2 acetylate APAP-Cys to APAP-Mer

NAT1,2 acetylate APAP-Cys to APAP-Mer

Stable Identifier

R-HSA-9753676

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Human arylamine N-acetyltransferases (NATs) are expressed as two polymorphic isoforms, NAT1 and NAT2, which have toxicologically significant functions in the detoxification of xenobiotic arylamines by N-acetylation (Liu et al. 2009, Klaassen 2013). NAT1 is located in virtually every tissue whereas NAT2 is mainly expressed in the liver and gut. Slow acetylators of polymorphic NAT2 may suffer more often from side-effects of NAT substrates than fast acetylators due to its inhibition by many drugs (Chien et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
19842618	Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines Liu, L, Wagner, CR, Hanna, PE	Chem Res Toxicol	2009
9024171	Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid Chien, JY, Peter, RM, Nolan, CM, Wartell, C, Slattery, JT, Nelson, SD, Carithers, RL, Thummel, KE	Clin Pharmacol Ther	1997