Signaling by RAS GAP mutants

Stable Identifier
R-HSA-9753510
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signaling by RAS GAP mutants
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This pathway describes RAS mutants whose intrinsic GTPase activity can't be stimulated by GTPase activating proteins (GAPs). These RAS mutants therefore support increased RAS pathway activity (reviewed in Prior et al, 2012; Pylayeva and Gupta, 2011, King et al, 2013; Cox and Der, 2010).
Literature References
PubMed ID Title Journal Year
21993244 RAS oncogenes: weaving a tumorigenic web

Grabocka, E, Pylayeva-Gupta, Y, Bar-Sagi, D

Nat. Rev. Cancer 2011
23443682 Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis

Lapinski, PE, Lubeck, BA, King, PD

Sci Signal 2013
22589270 A comprehensive survey of Ras mutations in cancer

Lewis, PD, Mattos, C, Prior, IA

Cancer Res. 2012
21686117 Ras history: The saga continues

Der, CJ, Cox, AD

Small GTPases 2010
Participants
Events
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as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database
Reviewed
Stephens, RM  (2016-08-05)
Created
Rothfels, K  (2021-09-08)
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