Reactome | KCNJ3 [plasma membrane]

KCNJ3 [plasma membrane]

Stable Identifier

R-HSA-975310

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein-activated inward rectifier potassium channel 1, IRK3_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Inwardly rectifying K+ channels (Homo sapiens)
    - G protein gated Potassium channels (Homo sapiens)
      - Activation of G protein gated Potassium channels (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ3 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ3 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ3 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ3 [plasma membrane] (Homo sapiens)
- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ3 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ3 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ3 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48549 KCNJ3

Gene Names

KCNJ3, GIRK1

Chain

chain:1-501

Reference Genes

BioGPS Gene:3760 KCNJ3

COSMIC (genes):KCNJ3 KCNJ3

CTD Gene:3760 KCNJ3

dbSNP Gene:3760 KCNJ3

ENSEMBL:ENSG00000162989 KCNJ3

HGNC:6264 KCNJ3

KEGG Gene (Homo sapiens):3760 KCNJ3

Monarch:3760 KCNJ3

NCBI Gene:3760 KCNJ3

OMIM:601534 KCNJ3

UCSC:P48549 KCNJ3

Reference Transcript

Other Identifiers

0006130176

11740318_s_at

11740319_s_at

11753217_s_at

16886656

207141_s_at

207142_at

233059_at

2511164

2511165

2511166

2511169

2511170

2511171

2511184

2511185

2511186

2511190

2511192

33527_at

3760

8045795

A_14_P118109

A_14_P201641

A_23_P153986

GE80471

GO:0003013

GO:0003674

GO:0005242

GO:0005244

GO:0005515

GO:0005575

GO:0005886

GO:0006810

GO:0006811

GO:0006813

GO:0007267

GO:0008076

GO:0008150

GO:0009897

GO:0009986

GO:0015467

GO:0016020

GO:0016021

GO:0022857

GO:0030315

GO:0032991

GO:0034765

GO:0051602

GO:0055085

GO:0086089

GO:0086091

GO:0098688

GO:0098914

GO:0098915

GO:0099056

GO:0099625

GO:1901381

GO:1902282

GO:1990573

HMNXSV003003605

HMNXSV003023000

Hs.199776.0.S1_3p_at

ILMN_1684945

PH_hs_0022969

TC02000947.hg

U39196_at

g1055027_3p_a_at

g4504838_3p_at

Participates

as a member of

Kir3.x channels [plasma membrane] (Homo sapiens)

Inferred To

irk-2 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ3 [plasma membrane] (Caenorhabditis elegans)

kcnj3 [plasma membrane] (Xenopus tropicalis)

irk-3 [plasma membrane] (Caenorhabditis elegans)

Irk3 [plasma membrane] (Drosophila melanogaster)

irk-1 [plasma membrane] (Caenorhabditis elegans)

kcnj3b [plasma membrane] (Danio rerio)

KCNJ3 [plasma membrane] (Canis familiaris)

KCNJ3 [plasma membrane] (Gallus gallus)

KCNJ3 [plasma membrane] (Sus scrofa)

Kcnj3 [plasma membrane] (Mus musculus)

Kcnj3 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_002230.1, NP_001247439.1, NP_001247437.1, NP_001247438.1

Guide to Pharmacology - Targets

434

OpenTargets

ENSG00000162989

GeneCards

P48549

HPA

ENSG00000162989-KCNJ3

Ensembl

ENSG00000162989, ENSP00000295101, ENSP00000438410, ENST00000295101, ENST00000544049

PRO

P48549

Pharos - Targets

P48549

GlyGen

P48549

HMDB Protein

HMDBP08741

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