Reactome | GABRA3 [plasma membrane]

GABRA3 [plasma membrane]

Stable Identifier

R-HSA-975289

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-3, GBRA3_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA3 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA3 [plasma membrane] (Homo sapiens)
      - NPTN binds GABA A receptors (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA3 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA3 [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA:NPTN [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
        
        GABR heteropentamers [plasma membrane] (Homo sapiens)
        
        2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA3 [plasma membrane] (Homo sapiens)
        
        2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
        
        GABRAs [plasma membrane] (Homo sapiens)
        
        GABRA3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P34903 GABRA3

Gene Names

GABRA3

Chain

signal peptide:1-28, chain:29-492

Reference Genes

BioGPS Gene:2556 GABRA3

COSMIC (genes):GABRA3 GABRA3

CTD Gene:2556 GABRA3

dbSNP Gene:2556 GABRA3

ENSEMBL:ENSG00000011677 GABRA3

ENSEMBL_homo_sapiens_GENE:ENSG00000011677.13 GABRA3

HGNC:4077 GABRA3

KEGG Gene (Homo sapiens):2556 GABRA3

Monarch:2556 GABRA3

NCBI Gene:2556 GABRA3

OMIM:305660 GABRA3

UCSC:P34903 GABRA3

Reference Transcript

RefSeq:NM_000808.3 GABRA3

Other Identifiers

11736402_at

11736403_a_at

17115014

207210_PM_at

207210_at

2556

31726_at

4026078

4026079

4026080

4026081

4026082

4026088

4026090

4026092

4026094

4026098

4026099

4026100

4026105

4026107

4026108

4026109

4026110

4026117

8175696

A28102_at

A_23_P125618

GE58788

GO:0004888

GO:0004890

GO:0005215

GO:0005216

GO:0005230

GO:0005237

GO:0005254

GO:0005515

GO:0005886

GO:0006811

GO:0006821

GO:0007214

GO:0008503

GO:0016020

GO:0022851

GO:0023052

GO:0032590

GO:0034220

GO:0034707

GO:0043005

GO:0045202

GO:0045211

GO:0051932

GO:0055085

GO:0060078

GO:0060089

GO:0098794

GO:1902476

GO:1902711

HMNXSV003012637

ILMN_1715551

PH_hs_0006892

TC0X001493.hg

g4557602_3p_at

Participates

as a member of

GABRAs [plasma membrane] (Homo sapiens)

Inferred To

GABRA3 [plasma membrane] (Bos taurus)

GABRA3 [plasma membrane] (Canis familiaris)

GABRA3 [plasma membrane] (Gallus gallus)

GABRA3 [plasma membrane] (Sus scrofa)

Gabra3 [plasma membrane] (Mus musculus)

Gabra3 [plasma membrane] (Rattus norvegicus)

Grd [plasma membrane] (Drosophila melanogaster)

lgc-36 [plasma membrane] (Caenorhabditis elegans)

gabra3 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000799.1

ZINC - World Drugs

GBRA3_HUMAN

Guide to Pharmacology - Targets

406

OpenTargets

ENSG00000011677

ZINC - FDA approved

GBRA3_HUMAN

ZINC - Substances

GBRA3_HUMAN

ZINC target

P34903

PRO

P34903

HPA

ENSG00000011677-GABRA3

GeneCards

P34903

Ensembl

ENSG00000011677, ENSP00000443527, ENST00000535043, ENST00000370314, ENSP00000359337

Pharos - Targets

P34903

Orphanet

18417

ZINC - Predictions - Purchasable

GBRA3_HUMAN

HMDB Protein

HMDBP08200