Reactome | KCNJ12 [plasma membrane]

KCNJ12 [plasma membrane]

Stable Identifier

R-HSA-975282

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ATP-sensitive inward rectifier potassium channel 12, IRK12_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Inwardly rectifying K+ channels (Homo sapiens)
    - Classical Kir channels (Homo sapiens)
      - KCNJs transport K+ from the extracellular region to cytosol (Homo sapiens)
        
        KCNJ tetramer [plasma membrane] (Homo sapiens)
        
        KCNJs [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)
    - G protein gated Potassium channels (Homo sapiens)
      - Activation of G protein gated Potassium channels (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)
- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir2.1:Kirx.x heterotetramer [plasma membrane] (Homo sapiens)
        
        Kirx.x that interacts with Kir2.1 [plasma membrane] (Homo sapiens)
        
        KCNJ12 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14500 KCNJ12

Gene Names

KCNJ12, IRK2, KCNJN1

Chain

chain:1-433

Reference Genes

BioGPS Gene:3768 KCNJ12

COSMIC (genes):KCNJ12 KCNJ12

CTD Gene:3768 KCNJ12

dbSNP Gene:3768 KCNJ12

ENSEMBL:ENSG00000184185 KCNJ12

HGNC:6258 KCNJ12

KEGG:hsa:3768 KCNJ12

Monarch:3768 KCNJ12

NCBI Gene:3768 KCNJ12

OMIM:602323 KCNJ12

UCSC:Q14500 KCNJ12

Reference Transcript

Other Identifiers

11727713_at

11727714_at

16832293

207110_PM_at

207110_at

208567_PM_s_at

208567_s_at

232289_PM_at

232289_at

34537_at

3714784

3714785

3714786

3714795

3714799

3714800

3714801

3714802

3714804

3715068

3715069

3768

8005726

ADDON002905.hg

A_14_P100220

A_23_P129821

A_24_P339429

GE57739

GE799491

GO:0003012

GO:0005215

GO:0005242

GO:0005515

GO:0005886

GO:0006813

GO:0006936

GO:0008016

GO:0016020

GO:0034220

GO:0034702

GO:0034765

GO:0051289

GO:0055085

GO:0065003

GO:1990573

HMNXSV003004902

Hs.200629.0.S1_3p_at

ILMN_1794200

L36069_at

PH_hs_0011768

PH_hs_0030884

TC17000298.hg

TC17002124.hg

g10337590_3p_at

g4504844_3p_s_at

Participates

as a member of

Inferred To

kcnj12b [plasma membrane] (Danio rerio)

irk-2 [plasma membrane] (Caenorhabditis elegans)

Irk1 [plasma membrane] (Drosophila melanogaster)

KCNJ12 [plasma membrane] (Bos taurus)

KCNJ12 [plasma membrane] (Canis familiaris)

KCNJ12 [plasma membrane] (Gallus gallus)

KCNJ12 [plasma membrane] (Mus musculus)

KCNJ12 [plasma membrane] (Rattus norvegicus)

KCNJ12 [plasma membrane] (Sus scrofa)

irk-3 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ12 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ12 [plasma membrane] (Drosophila melanogaster)

Irk3 [plasma membrane] (Drosophila melanogaster)

irk-1 [plasma membrane] (Caenorhabditis elegans)

kcnj12 [plasma membrane] (Xenopus tropicalis)

Irk2 [plasma membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

431

ENSEMBL

ENSP00000328150, ENST00000583088, ENSP00000463778, ENSG00000184185, ENST00000331718

OpenTargets

ENSG00000184185

GeneCards

KCNJ12

HPA

ENSG00000184185-KCNJ12

PRO

Q14500

Pharos - Targets

Q14500

HMDB Protein

HMDBP08736

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.609	2