Reactome | MyD88 interacts with the activated TLR receptor 7, 8 or 9

MyD88 interacts with the activated TLR receptor 7, 8 or 9

Stable Identifier

R-HSA-975175

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

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MyD88 interacts with the activated TLR receptor 7, 8 or 9

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MyD88 binds to IRAK (IL-1 receptor-associated kinase) and the receptor heterocomplex (the signaling complex) and thereby mediates the association of IRAK with the receptor. MyD88 therefore couples a serine/threonine protein kinase to the receptor complex.

Literature References

PubMed ID	Title	Journal	Year
9430229	MyD88: an adapter that recruits IRAK to the IL-1 receptor complex Wesche, H, Henzel, WJ, Shillinglaw, W, Li, S, Cao, Z	Immunity	1997
15361868	Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 Kawai, T, Sato, S, Ishii, KJ, Coban, C, Hemmi, H, Yamamoto, M, Terai, K, Matsuda, M, Inoue, J, Uematsu, S, Takeuchi, O, Akira, S	Nat Immunol	2004
12447442	The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors Horng, T, Barton, GM, Flavell, RA, Medzhitov, R	Nature	2002
15492225	Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling Honda, K, Yanai, H, Mizutani, T, Negishi, H, Shimada, N, Suzuki, N, Ohba, Y, Takaoka, A, Yeh, WC, Taniguchi, T	Proc Natl Acad Sci U S A	2004