MyD88 interacts with the activated TLR receptor 7, 8 or 9

Stable Identifier
R-HSA-975175
Type
Reaction
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
endosome membrane, cytosol
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MyD88 interacts with the activated TLR receptor 7, 8 or 9
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MyD88 binds to IRAK (IL-1 receptor-associated kinase) and the receptor heterocomplex (the signaling complex) and thereby mediates the association of IRAK with the receptor. MyD88 therefore couples a serine/threonine protein kinase to the receptor complex.

Literature References
PubMed ID Title Journal Year
9430229 MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

Henzel, WJ, Wesche, H, Li, S, Cao, Z, Shillinglaw, W

Immunity 1997
15361868 Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T, Takeuchi, O, Inoue, J, Matsuda, M, Terai, K, Ishii, KJ, Sato, S, Yamamoto, M, Akira, S, Uematsu, S, Coban, C, Hemmi, H

Nat Immunol 2004
12447442 The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Barton, GM, Horng, T, Medzhitov, R, Flavell, RA

Nature 2002
15492225 Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

Yeh, WC, Shimada, N, Ohba, Y, Mizutani, T, Yanai, H, Suzuki, N, Honda, K, Takaoka, A, Taniguchi, T, Negishi, H

Proc Natl Acad Sci U S A 2004
Participants
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Orthologous Events
Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
Authored
Shamovsky, V  (2010-08-25)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
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