MyD88 binds to IRAK (IL-1 receptor-associated kinase) and the receptor heterocomplex (the signaling complex) and thereby mediates the association of IRAK with the receptor. MyD88 therefore couples a serine/threonine protein kinase to the receptor complex.
Kawai, T, Sato, S, Ishii, KJ, Coban, C, Hemmi, H, Yamamoto, M, Terai, K, Matsuda, M, Inoue, J, Uematsu, S, Takeuchi, O, Akira, S
Wesche, H, Henzel, WJ, Shillinglaw, W, Li, S, Cao, Z
Horng, T, Barton, GM, Flavell, RA, Medzhitov, R
Honda, K, Yanai, H, Mizutani, T, Negishi, H, Shimada, N, Suzuki, N, Ohba, Y, Takaoka, A, Yeh, WC, Taniguchi, T
© 2021 Reactome