Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9

Stable Identifier
R-HSA-975134
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
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Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
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Second, Thr387 in the activation loop is phosphorylated, leading to full enzymatic activity.
Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C

J Biol Chem 2004
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane]

Physical Entity
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Shamovsky, V  (2010-08-25)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
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