IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]

Stable Identifier
R-HSA-975113
Type
Complex
Species
Homo sapiens
Related Species
Influenza A virus, Human immunodeficiency virus 1, Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
20485341 Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling

Lo, YC, Lin, SC, Wu, H

Nature 2010
15767370 Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

Takeuchi, O, Yamamoto, M, Matsuda, M, Ishii, KJ, Sato, S, Akira, S, Kawai, T, Kato, H, Coban, C, Hirotani, T, Uematsu, S, Takeshita, F

J Exp Med 2005
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