Reactome | IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9

Stable Identifier

R-HSA-975113

Type

Complex

Species

Homo sapiens

Compartment

endosome membrane

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
20485341	Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling	Nature	2010
15767370	Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction	J Exp Med	2005

Participants

components

Participant Of

output

IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9.

Inferred To

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Bos taurus)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Canis familiaris)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Danio rerio)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Drosophila melanogaster)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Gallus gallus)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Mus musculus)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Rattus norvegicus)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Sus scrofa)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Taeniopygia guttata)

IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Xenopus tropicalis)

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