ALB binds ST

Stable Identifier
R-HSA-9750666
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Salicylate binds albumin
ReviewStatus
5/5
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Salicylate binds to multiple sites on serum albumin, but at therapeutic doses only one site seems relevant, for kinetic reason. The exact binding site is unknown. The binding is reversible (Reynolds & Cluff, 1960; Borgå et al, 1976; Shen et al, 1991).
Literature References
PubMed ID Title Journal Year
975718 Protein binding of salicylate in uremic and normal plasma

Borgå, O, Norlin, A, Ringberger, VA, Cederlöf, IO

Clin Pharmacol Ther 1976
13741103 Interaction of serum and sodium salicylate: changes during acute infection and its influence on pharmacological activity

REYNOLDS, RC, CLUFF, LE

Bull Johns Hopkins Hosp 1960
1783992 Model representation of salicylate pharmacokinetics using unbound plasma salicylate concentrations and metabolite urinary excretion rates following a single oral dose

McQueen, EG, Wanwimolruk, S, Roberts, MS, Purves, RD, Shen, J

J Pharmacokinet Biopharm 1991
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