Drug-induced formation of DNA interstrand crosslinks

Stable Identifier
R-HSA-9750126
Type
Pathway
Species
Homo sapiens
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This pathway describes how drugs commonly used in the treatment of cancer, psoriasis and severe atopic dermatitis produce DNA interstrand crosslinks that are repaired through the Fanconi anemia pathway. For review, please refer to Deans and West 2011, Fu et al. 2012, and Rycenga and Long 2018.

Literature References
PubMed ID Title Journal Year
29679802 The evolving role of DNA inter-strand crosslinks in chemotherapy

Rycenga, HB, Long, DT

Curr Opin Pharmacol 2018
21701511 DNA interstrand crosslink repair and cancer

Deans, AJ, West, SC

Nat. Rev. Cancer 2011
22237395 Balancing repair and tolerance of DNA damage caused by alkylating agents

Fu, D, Calvo, JA, Samson, LD

Nat. Rev. Cancer 2012
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