Reactome | CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA

CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA

Stable Identifier

R-HSA-9750016

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA

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2,5-Dihydroxybenzoate (gentisic acid, 2,5-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
25840124	Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450 Bojić, M, Sedgeman, CA, Nagy, LD, Guengerich, FP	Eur J Pharm Sci	2015
3342084	2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism Grootveld, M, Halliwell, B	Biochem Pharmacol	1988