CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA

Stable Identifier
R-HSA-9750016
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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2,5-Dihydroxybenzoate (gentisic acid, 2,5-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015).
Literature References
PubMed ID Title Journal Year
25840124 Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450

Nagy, LD, Guengerich, FP, Sedgeman, CA, Bojić, M

Eur J Pharm Sci 2015
3342084 2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism

Grootveld, M, Halliwell, B

Biochem Pharmacol 1988
Participants
Participates
Catalyst Activity

monooxygenase activity of CYP2,3 cytochromes [endoplasmic reticulum membrane]

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