Reactome | GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid

GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid

Stable Identifier

R-HSA-9750001

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

2,5-DHBA-CoA + glycine => gentisuric acid + Coenzyme A, 2,5-DHBA-CoA forms an amide bond with glycine

ReviewStatus

5/5

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GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid

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GLYAT-like enzymes catalyze the transfer of acyl groups from acyl-CoA onto glycine (Webster et al, 1976). Conjugation of 2,5-DHBA with glycine yields gentisuric acid which is detected after aspirin intake (Wilson et al., 1978).

Literature References

PubMed ID	Title	Journal	Year
7802672	Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver Mawal, YR, Qureshi, IA	Biochem Biophys Res Commun	1994
931988	Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man Webster, LT, Siddiqui, UA, Lucas, SV, Strong, JM, Mieyal, JJ	J Biol Chem	1976
3705620	The metabolism of aspirin in man: a population study Hutt, AJ, Caldwell, J, Smith, RL	Xenobiotica	1986