GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid

Stable Identifier
R-HSA-9750001
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
2,5-DHBA-CoA + glycine => gentisuric acid + Coenzyme A, 2,5-DHBA-CoA forms an amide bond with glycine
ReviewStatus
5/5
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GLYAT-like enzymes catalyze the transfer of acyl groups from acyl-CoA onto glycine (Webster et al, 1976). Conjugation of 2,5-DHBA with glycine yields gentisuric acid which is detected after aspirin intake (Wilson et al., 1978).
Literature References
PubMed ID Title Journal Year
7802672 Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver

Qureshi, IA, Mawal, YR

Biochem Biophys Res Commun 1994
931988 Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man

Strong, JM, Mieyal, JJ, Lucas, SV, Webster, LT, Siddiqui, UA

J Biol Chem 1976
3705620 The metabolism of aspirin in man: a population study

Smith, RL, Caldwell, J, Hutt, AJ

Xenobiotica 1986
Participants
Participates
Catalyst Activity

glycine N-benzoyltransferase activity of GLYAT-like proteins [mitochondrial matrix]

Orthologous Events
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