Reactome | CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA

CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA

Stable Identifier

R-HSA-9749986

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

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CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA

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2,3-Dihydroxybenzoate (2,3-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015)

Literature References

PubMed ID	Title	Journal	Year
25840124	Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450 Nagy, LD, Guengerich, FP, Sedgeman, CA, Bojić, M	Eur J Pharm Sci	2015
3342084	2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism Grootveld, M, Halliwell, B	Biochem Pharmacol	1988