SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells

Stable Identifier
R-HSA-9749607
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, cytosol
ReviewStatus
5/5
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SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells
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Higher uptake of dissolved acetylsalicylate (ASA-) versus neutral acid shows there are transmembrane transport processes specific to ASA- or similar ions (Leonards, 1963). For salicylate, experiments with monolayers of Caco-2 cells have shown a mixture of pH-dependent passive and active influx, and one of the participating transport proteins is SLCO2B1 (formerly OATP-B). SLCO2B1 isoform 1 is the form expressed in the small intestine (Neuhoff et al, 2005; Koljonen et al, 2008). Based on this observation, it is likely that SLCO2B1 also transports ASA-.
Literature References
PubMed ID Title Journal Year
15911216 pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers

Neuhoff, S, Ungell, AL, Zamora, I, Artursson, P

Eur J Pharm Sci 2005
18582575 Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes

Koljonen, M, Rousu, K, Cierny, J, Kaukonen, AM, Hirvonen, J

Eur J Pharm Biopharm 2008
13929721 The influence of solubility on the rate of gastrointestinal absorption of aspirin

LEONARDS, JR

Clin Pharmacol Ther 1963
Participants
Input
Output
Participates
as an event of
Catalyst Activity

secondary active transmembrane transporter activity of SLCO2B1-1 [plasma membrane]

Physical Entity
SLCO2B1-1 [plasma membrane] (Homo sapiens)
Activity
secondary active transmembrane transporter activity (GO:0015291)
Orthologous Events
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Bos taurus)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Caenorhabditis elegans)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Canis familiaris)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Danio rerio)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Drosophila melanogaster)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Gallus gallus)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Mus musculus)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Rattus norvegicus)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Sus scrofa)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Xenopus tropicalis)
Authored
Stephan, R  (2021-08-03)
Reviewed
Huddart, R  (2021-10-13)
Created
Stephan, R  (2021-08-04)
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