SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells

Stable Identifier
R-HSA-9749607
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, cytosol
ReviewStatus
5/5
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SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells
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Higher uptake of dissolved acetylsalicylate (ASA-) versus neutral acid shows there are transmembrane transport processes specific to ASA- or similar ions (Leonards, 1963). For salicylate, experiments with monolayers of Caco-2 cells have shown a mixture of pH-dependent passive and active influx, and one of the participating transport proteins is SLCO2B1 (formerly OATP-B). SLCO2B1 isoform 1 is the form expressed in the small intestine (Neuhoff et al, 2005; Koljonen et al, 2008). Based on this observation, it is likely that SLCO2B1 also transports ASA-.
Literature References
PubMed ID Title Journal Year
15911216 pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers

Neuhoff, S, Zamora, I, Ungell, AL, Artursson, P

Eur J Pharm Sci 2005
18582575 Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes

Cierny, J, Rousu, K, Kaukonen, AM, Hirvonen, J, Koljonen, M

Eur J Pharm Biopharm 2008
13929721 The influence of solubility on the rate of gastrointestinal absorption of aspirin

LEONARDS, JR

Clin Pharmacol Ther 1963
Participants
Input
Output
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as an event of
Catalyst Activity

sodium-independent organic anion transmembrane transporter activity of SLCO2B1-1 [plasma membrane]

Physical Entity
SLCO2B1-1 [plasma membrane] (Homo sapiens)
Activity
sodium-independent organic anion transmembrane transporter activity (GO:0015347)
Orthologous Events
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Bos taurus)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Caenorhabditis elegans)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Canis familiaris)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Danio rerio)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Drosophila melanogaster)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Gallus gallus)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Mus musculus)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Rattus norvegicus)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Sus scrofa)
SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Xenopus tropicalis)
Authored
Stephan, R  (2021-08-03)
Reviewed
Huddart, R  (2021-10-13)
Created
Stephan, R  (2021-08-04)
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