ASA- acetylates ALB

Stable Identifier
R-HSA-9749590
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Albumin gets acetylated by ASA
ReviewStatus
5/5
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ASA- acetylates ALB
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Acetylsalicylate (ASA-) acetylates several lysine residues on albumin, which subsequently release their acetate over a long time span. This pseudo-esterase activity contributes to overall aspirin esterase activity in blood plasma (Hawkins et al, 1969; Liyasova et al, 2010).

Literature References
PubMed ID Title Journal Year
19836360 Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545

Schopfer, LM, Liyasova, MS, Lockridge, O

Biochem Pharmacol 2010
5773090 Structural changes in human serum albumin induced by ingestion of acetylsalicylic acid

Crawford, IP, Pinckard, RN, Farr, RS, Hawkins, D

J Clin Invest 1969
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Orthologous Events
ASA- acetylates ALB (Bos taurus)
ASA- acetylates ALB (Gallus gallus)
ASA- acetylates ALB (Mus musculus)
ASA- acetylates ALB (Rattus norvegicus)
ASA- acetylates ALB (Sus scrofa)
ASA- acetylates ALB (Xenopus tropicalis)
Authored
Stephan, R  (2021-08-03)
Reviewed
Huddart, R  (2021-10-13)
Created
Stephan, R  (2021-08-04)
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