Reactome | SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes

SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes

Stable Identifier

R-HSA-9749583

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, cytosol

Synonyms

SLC22A7 transports ASA-,ST into liver cells

ReviewStatus

5/5

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SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes

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SLC22A7 is a sodium-independent multispecific organic anion transporter, expressed in liver and kidney, that also has acetylsalicylate (ASA-) and salicylate (ST) as substrate (Sekine et al, 1998; Sun et al, 2001). Uptake of ASA- by rat hepatocytes is slow and caused by an apparently linear process (Iwamoto et al, 1984).

Literature References

PubMed ID	Title	Journal	Year
9650585	Identification of multispecific organic anion transporter 2 expressed predominantly in the liver Endou, H, Cha, SH, Kanai, Y, Apiwattanakul, N, Tsuda, M, Nakajima, N, Sekine, T	FEBS Lett	1998
11327718	Isolation of a family of organic anion transporters from human liver and kidney Wu, RR, Sun, W, van Poelje, PD, Erion, MD	Biochem Biophys Res Commun	2001
6487359	Difference in hepatic uptake kinetics of aspirin and salicylamide in rats Iwamoto, K, Furune, Y, Watanabe, J	Biochem Pharmacol	1984