Reactome | Formation of MCM2-7 complex

Formation of MCM2-7 complex

Stable Identifier

R-HSA-9749253

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Six homologous minichromosome maintenance proteins, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7, form the evolutionarily conserved MCM2-7 complex, which functions as the core eukaryotic replicated DNA helicase. The structure of the complex is conserved from yeast (Li et al. 2015) to humans (Boskovic et al. 2016), representing an open hexameric ring, with a gate between subunits MCM2 and MCM5. The gate is thought to close and open the MCM2-7 ring to encircle DNA. Each MCM subunit contains an N-terminal DNA interacting and assembly domain and a C-terminal ATP-binding domain.

Literature References

PubMed ID	Title	Journal	Year
27249176	Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA Saligram Prabhakar, B, Méndez, J, Boskovic, J, Montoya, G, Bragado-Nilsson, E, Martínez-Gago, J, Yefimenko, I, Muñoz, S	Cell Cycle	2016
26222030	Structure of the eukaryotic MCM complex at 3.8 Å Yang, M, Gao, N, Tye, BK, Zhai, Y, Li, N, Lei, J, Zhang, Y, Li, W	Nature	2015