Reactome | MCM8 binds CDC6

MCM8 binds CDC6

Stable Identifier

R-HSA-9749215

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MCM8, a member of the MCM family of proteins, forms a complex with CDC6 (Volkening and Hoffmann 2005; Wang et al. 2021). MCM8 may facilitate association of CDC6 with the origin of replication complex (ORC) either directly (Volkening and Hoffmann 2005) or by increasing the protein stability of CDC6 (Wang et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
15684404	Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin Hoffmann, I, Volkening, M	Mol Cell Biol	2005
34131285	MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors Song, Y, Han, S, Wang, R, Jiang, Y, Wang, X, Hu, T, Zhang, L, Zhang, D	Oncogene	2021