ORC1 binds to H4K20me2

Stable Identifier
R-HSA-9749197
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Besides binding to nucleosome-free replication origin DNA, ORC1 interacts with neighboring nucleosomes (Hizume et al. 2013). The interaction of ORC1 with nucleosomes may require specific epigenetic marks on nucleosomes, and may be disrupted by ORC1 mutations associated with the Meier-Gorlin Syndrome (Zhang et al. 2015). In particular, a bromo adjacent homology (BAH) domain of ORC1 has been shown to bind to histone H4 dimethylated at lysine 21 (H4K20me2 mark), which is enriched at replication origins. Binding of ORC1 to H4K20me2 facilitates ORC1 binding to replication origins and ORC chromatin loading (Kuo et al. 2012, Zhang et al. 2015).

Literature References
PubMed ID Title Journal Year
22398447 The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome

Kuo, AJ, Song, J, Cheung, P, Ishibe-Murakami, S, Yamazoe, S, Chen, JK, Patel, DJ, Gozani, O

Nature 2012
25689043 A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association

Zhang, W, Sankaran, S, Gozani, O, Song, J

ACS Chem Biol 2015
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