Reactome | NME1:2 hexamer phosphorylates 6TGDP to 6TGTP

NME1:2 hexamer phosphorylates 6TGDP to 6TGTP

Stable Identifier

R-HSA-9748999

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

6TGDP--NME1:2-->6TGTP

ReviewStatus

5/5

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NME1:2 hexamer phosphorylates 6TGDP to 6TGTP

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6-thioguanine nucleotides (6-TGNs) consist of 6-thio(deoxy)guanosine 5'-monophosphate (T(d)GMP), -diphosphate (T(d)GDP), and -triphosphate (T(d)GTP), representing the pharmacologically-active metabolites involved in drug action of thiopurines.

Nucleoside diphosphate kinase (NME) plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 forms a hexameric complex with NME2 and this complex is thought to phosphorylate 6-thioguanosine diphosphate (6TGDP) to 6-thioguanosine triphosphate (6TGTP) (Karner et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20216118	Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy? Karner, S, Shi, S, Fischer, C, Schaeffeler, E, Neurath, MF, Herrlinger, KR, Hofmann, U, Schwab, M	Ther Drug Monit	2010